BioEssays

Cover image for Vol. 32 Issue 8

August 2010

Volume 32, Issue 8

Pages 645–735

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
    1. BioEssays 8/2010

      Gustavo Caetano-Anollés and Jay Mittenthal

      Article first published online: 20 JUL 2010 | DOI: 10.1002/bies.201090031

      Cover Photograph:The interplay of protein stability and function in sequence space, as discussed by Gustavo Caetano-Anollés and Jay Mittenthal on pages 655–658 of this issue. The grid diagram depicts a multidimensional sequence space (flattened into a two-dimensional view) of protein sequences that change into others by single-point mutations (the third dimension represents thermodynamic stability). All proteins in the grid fold into a same three-dimensional (3D) structure, a four-helix bundle structure typical of cytochrome cb562 (a metalloprotein used to study metal-induced protein stability and homodimerization; PDB entry 3L1M). In the diagram, cytochrome proteins drift in evolution along the grid (colored regions) while folding into the same 3D structure and while searching for increases in protein stability (i.e. dents in the grid). This results in sections of the proteins that are evolutionarily conserved due to constraints imposed by the interplay of stability and function (grey regions close to metal-binding sites in the bundles). Image and concept developed by Derek Caetano-Anollés.

  2. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
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  3. Contents and highlights of this issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
    1. You have free access to this content
      BioEssays 8/2010 (pages 646–647)

      Article first published online: 20 JUL 2010 | DOI: 10.1002/bies.201090030

  4. Insights & Perspectives

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
    1. Ex laboratorio

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    2. Ideas & Speculations

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  5. Prospects & Overviews

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
    1. Recently in press

    2. Review essays

      What an epigenome remembers (pages 659–668)

      Ulrike C. Lange and Robert Schneider

      Article first published online: 20 JUL 2010 | DOI: 10.1002/bies.201000030

    3. Setting and resetting of epigenetic marks in malignant transformation and development (pages 669–679)

      Holger Richly, Martin Lange, Elisabeth Simboeck and Luciano Di Croce

      Article first published online: 20 JUL 2010 | DOI: 10.1002/bies.201000016

    4. Problems & Paradigms

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  6. Biotec Visions

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
    1. Biotec Visions: BioEssays 8/2010

      Article first published online: 22 SEP 2010 | DOI: 10.1002/bies.201090044

  7. Next Issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Biotec Visions
    8. Next Issue
    1. BioEssays – Next Issue

      Article first published online: 22 SEP 2010 | DOI: 10.1002/bies.201090045

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