BioEssays

Cover image for Vol. 33 Issue 11

November 2011

Volume 33, Issue 11

Pages 785–890

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. BioEssays 11/2011

      Version of Record online: 17 OCT 2011 | DOI: 10.1002/bies.201190058

      A guide to stem cell identification: Progress and challenges in system-wide predictive testing with complex biomarkers. Novel, systems wide tests can reliably map stem cell phenotypes and potentially replace cumbersome in vivo or in vitro assays. On pages 880-890 Williams, Schuldt and Müller describe new concepts and advances that have lead to the development of a first generation data driven tool for cellular phenotype assessment.

      For the graph, human embryonic stem cells (red dots) were differentiated into neural precursor cells (blue dots) and gene expression microarrays hybridized with these samples were nalyzed with PluriTest (www.pluritest.org). The two PluriTest Scores (“Pluripotency Score” and the model-fit assessment score “Novelty Score”) for each sample are plotted on a third dimension representing an empirical density distribution derived from a test dataset with several hundreds of stem cells and somatic samples. Red surfaces values on the PluriTest landscape indicate where pluripotent samples are usually mapped by the algorithm, blue areas indicate empirical scores for somatic samples.

      Cover by I. Garitaonandia, J. Goldmann, F.-J. Müller

  2. Back Cover

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. BioEssays 11/2011

      Version of Record online: 19 OCT 2011 | DOI: 10.1002/bies.201190062

      Thumbnail image of graphical abstract

      FBW7 in cancer drug resistance. The occurrence of resistance to chemotherapeutic agents constitutes a major problem in cancer treatment. In their article on pages 851-859, Wang et al. elucidate the role of the F-box and WD repeat domain-containing 7 (FBW7) tumor suppressor in this process. On one hand, FBW7-deficient cells are addicted to the elevated levels of the Mcl-1 pro-survival factor, rendering these cells more sensitive to the chemotherapeutic drug sorafenib. On the other hand, in the absence of this protein, taxol- and vincristineinduced cell death is inhibited. Furthermore, inhibition of tumor growth by ABT-737 and gamma secretase inhibitor (GSI) is impaired. Because of its central role in cancer drug resistance, targeting of FBW7 may open a new therapeutic window for drug administration.

      Backcover by Z. Wang and W. Wei

  3. Editorial

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. You have free access to this content
  4. Contents and highlights of this issue

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. You have free access to this content
      BioEssays 11/2011 (pages 786–788)

      Version of Record online: 17 OCT 2011 | DOI: 10.1002/bies.201190056

  5. Highlights from other journals

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
  6. Insights & Perspectives

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. Idea to watch

    2. Hypotheses

    3. Think again

      Intracellular antibody-mediated immunity and the role of TRIM21 (pages 803–809)

      William A. McEwan, Donna L. Mallery, David A. Rhodes, John Trowsdale and Leo C. James

      Version of Record online: 29 AUG 2011 | DOI: 10.1002/bies.201100093

      Thumbnail image of graphical abstract

      It was discovered recently that antibodies not only act outside of cells but that they can also enter cells to mediate an intracellular immune response by binding to the intracellular antibody receptor TRIM21, which then directs antibody-covered virions to the ubiquitin-proteasome system for degradation.

    4. Planctomycetes and eukaryotes: A case of analogy not homology (pages 810–817)

      James O. McInerney, William F. Martin, Eugene V. Koonin, John F. Allen, Michael Y. Galperin, Nick Lane, John M. Archibald and T. Martin Embley

      Version of Record online: 22 AUG 2011 | DOI: 10.1002/bies.201100045

    5. Commentary

    6. Incorporation of phylogeny in biological diversity measurement: Drawbacks of extensively used indices, and advantages of quadratic entropy (pages 819–822)

      Bastien Mérigot and Jean-Claude Gaertner

      Version of Record online: 5 SEP 2011 | DOI: 10.1002/bies.201100103

      Thumbnail image of graphical abstract

      Using the indices δ+ and δ* for assessing phylogenetic diversity may lead to spurious results and interpretations; it can bias recommendations for conservation and lead to inappropriate management decisions. Therefore these indices should be avoided and other indices based on quadratic entropy (Qδ+ and Q) should be used instead.

  7. Prospects & Overviews

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. Recently in press

    2. Review essays

      You have full text access to this OnlineOpen article
    3. Challenges in studying genomic structural variant formation mechanisms: The short-read dilemma and beyond (pages 840–850)

      Megumi Onishi-Seebacher and Jan O. Korbel

      Version of Record online: 30 SEP 2011 | DOI: 10.1002/bies.201100075

      Thumbnail image of graphical abstract

      Structural variants (SVs) are responsible for a large degree of genetic variation among individuals and have also been implicated in a number of diseases and complex traits. However, short DNA reads typically generated by next-generation sequencing technologies can lead to a bias in the types of SVs most easily detected (short read dilemma). Novel approaches and integration of other sources of information will help overcome this dilemma.

    4. The two faces of FBW7 in cancer drug resistance (pages 851–859)

      Zhiwei Wang, Hidefumi Fukushima, Daming Gao, Hiroyuki Inuzuka, Lixin Wan, Alan W. Lau, Pengda Liu and Wenyi Wei

      Version of Record online: 30 AUG 2011 | DOI: 10.1002/bies.201100101

      Thumbnail image of graphical abstract

      The ubiquitin ligase FBW7 acts as a tumor suppressor by targeting various oncogenic proteins for ubiquitination. Furthermore, loss of FBW7 is linked to drug resistance and this protein may therefore represent a novel therapeutic target to increase drug sensitivity of cancer cells to conventional chemotherapies.

    5. Problems & Paradigms

      Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations (pages 860–869)

      Nick Lane

      Version of Record online: 16 SEP 2011 | DOI: 10.1002/bies.201100051

      Thumbnail image of graphical abstract

      In eukaryotic cells, coadaptation of mitochondrial and nuclear genomes may be behind the origin of two sexes, and dictate fertility, speciation, and adaptability in youth. The benefits, however, entail costs later in life: faster ageing and more age-related diseases.

    6. You have full text access to this OnlineOpen article
    7. Methods, Models & Techniques

      A guide to stem cell identification: Progress and challenges in system-wide predictive testing with complex biomarkers (pages 880–890)

      Roy Williams, Bernhard Schuldt and Franz-Josef Müller

      Version of Record online: 8 SEP 2011 | DOI: 10.1002/bies.201100073

      Thumbnail image of graphical abstract

      PluriTest is a first generation tool for the unbiased identification and characterization of human pluripotent stem cells which utilizes all the information contained on a microarray and abandons the conventional stem cell marker concept.

  8. Biotec Visions

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. You have free access to this content
      BiotecVisions 2011, Oktober (pages A1-A8)

      Version of Record online: 17 OCT 2011 | DOI: 10.1002/bies.201190059

  9. Next Issue

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Editorial
    5. Contents and highlights of this issue
    6. Highlights from other journals
    7. Insights & Perspectives
    8. Prospects & Overviews
    9. Biotec Visions
    10. Next Issue
    1. You have free access to this content
      BioEssays – Next Issue

      Version of Record online: 17 OCT 2011 | DOI: 10.1002/bies.201190060

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