BioEssays

Cover image for Vol. 33 Issue 6

June 2011

Volume 33, Issue 6

Pages 397–479

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. BioEssays 6/2011

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/bies.201190026

      Cover Photograph: Seeing near visual threshold requires optimizing the signal-to-noise ratio of single-photon responses. Most mammalian species exhibit exquisite night vision that is initiated by G-protein coupled signaling cascades in both the retinal rod photoreceptors and the second order rod bipolar cells. In this issue (pages 438–447), Pahlberg and Sampath describe how these and other signaling mechanisms set the threshold for seeing. In rods, the absorption of a photon by rhodopsin leads to an amplifying cascade of events that alters the membrane potential, thereby reducing glutamate release onto the dendrites of rod bipolar cells. Rod bipolar cells sense glutamate release from rods using metabotropic glutamate receptors, mGluR6, whose activity leads to the closure of TRPM1 cation channels. The properties of these signaling cascades are crucial for setting high visual sensitivity, the rod phototransduction cascade amplifying the single-photon response and the rod bipolar signaling cascade suppressing noise from rods not absorbing light.

      Cover by J. Pahlberg and A. P. Sampath

  2. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. You have free access to this content
      Toward a physical biology (page 397)

      Suzannah Rutherford

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/bies.201190023

  3. Contents and highlights of this issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. You have free access to this content
      BioEssays 6/2011 (pages 398–399)

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/bies.201190024

  4. Insights & Perspectives

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. Ex laboratorio

    2. Hypotheses

    3. Ideas & Speculations

      Harvesting the biological potential of the human gut microbiome (pages 414–418)

      Benjamin P. Willing, L. Caetano M. Antunes, Kristie M. Keeney, Rosana B. R. Ferreira and B. Brett Finlay

      Version of Record online: 15 APR 2011 | DOI: 10.1002/bies.201100030

      Thumbnail image of graphical abstract

      Identifying the properties and molecules of the intestinal microbiome may help our understanding of various diseases and therefore facilitate their treatment; from excluding pathogens to manipulation of the immune system and regulation of non-intestinal sites.

    4. Basophils: Important emerging players in allergic and anti-parasite responses (pages 423–426)

      Christian Schwartz and David Voehringer

      Version of Record online: 15 APR 2011 | DOI: 10.1002/bies.201100028

      Thumbnail image of graphical abstract

      The recent development of transgenic mouse strains depleted in basophils has helped in elucidating the diverse functions of basophils in the primary in secondary immune responses: from acting as antigen-presenting cells and contributing to B cell activation to their role in allergic inflammation, worm expulsion and tick resistance.

    5. Commentary

      Comment on “Does constructive neutral evolution play an important role in the origin of cellular complexity?” DOI 10.1002/bies.201100010 (pages 427–429)

      W. Ford Doolittle, Julius Lukeš, John M. Archibald, Patrick J. Keeling and Michael W. Gray

      Version of Record online: 29 APR 2011 | DOI: 10.1002/bies.201100039

  5. Prospects & Overviews

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. Recently in press

    2. Review essays

    3. Problems & Paradigms

  6. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. You have free access to this content
      Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges (pages 478–479)

      Zsuzsanna Izsvák, Perry B. Hackett, Laurence J. N. Cooper and Zoltán Ivics

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/bies.201190025

      This article corrects:

      Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

      Vol. 32, Issue 9, 756–767, Version of Record online: 22 JUL 2010

  7. Biotec Visions

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. Biotec Visions: BioEssays 6/2011

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/bies.201190027

  8. Next Issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Corrigendum
    8. Biotec Visions
    9. Next Issue
    1. BioEssays – Next Issue

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/bies.201190028

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