BioEssays

Cover image for Vol. 33 Issue 7

July 2011

Volume 33, Issue 7

Pages 481–556

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. BioEssays 7/2011

      Article first published online: 16 JUN 2011 | DOI: 10.1002/bies.201190033

      Cover Photograph: Through the looking glass: The role of metabolites. Cells contain a vast amount of small metabolites that may interact with proteins and thus regulate protein localization and turnover, protein-protein interactions and binding of proteins to nucleic acids among other things. In this issue (pages 485–489), Li and Snyder take a look at the different strategies used to discover metaboliteprotein interactions and identify several challenges faced by these approaches. A systematic investigation of metaboliteprotein interactions may help bridge the gap between genome-wide association studies and small molecule screening studies and therefore lead to disclosure of important aspects of physiology and pathology. These findings may ultimately even provide a short list of potential targets and small molecule candidates for drug development.

      Cover by X. Li and M. Snyder

  2. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. You have free access to this content
  3. Contents and highlights of this issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. You have free access to this content
      BioEssays 7/2011 (pages 482–483)

      Article first published online: 16 JUN 2011 | DOI: 10.1002/bies.201190030

  4. Highlights from other journals

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. You have free access to this content
  5. Insights & Perspectives

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. Ideas & Speculations

    2. Think again

      Why is it crucial to reintegrate pathology into cancer research? (pages 490–498)

      Jaime Rodriguez-Canales, Franziska C. Eberle, Elaine S. Jaffe and Michael R. Emmert-Buck

      Article first published online: 17 MAY 2011 | DOI: 10.1002/bies.201100017

      Thumbnail image of graphical abstract

      Pathology can act as a bridge between medicine and (basic) biology and play an important role in the characterization of cancer, thus being of great benefit to patients.

  6. Prospects & Overviews

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. Review essays

    2. The time of timing: How Polycomb proteins regulate neurogenesis (pages 519–528)

      Giuseppe Testa

      Article first published online: 1 JUN 2011 | DOI: 10.1002/bies.201100021

      Thumbnail image of graphical abstract

      Polycomb group factors target a wide variety of different genes, among them many tissue-specific transcription factors, and the precise and timely interplay of these factors also plays a vital role in neural development.

    3. Problems & Paradigms

      Retinal determination genes function along with cell-cell signals to regulate Drosophila eye development : Examples of multi-layered regulation by master regulators (pages 538–546)

      Nicholas E. Baker and Lucy C. Firth

      Article first published online: 24 MAY 2011 | DOI: 10.1002/bies.201000131

      Thumbnail image of graphical abstract

      Characterization of the enhancers responsible for eye expression as well as the dynamics of retinal determination gene expression themselves suggest a multilayered network whereby transcriptional regulation by either retinal determination genes or cell-cell signaling pathways can sometimes be indirect and mediated by other transcription factor intermediates.

    4. Methods, Models & Techniques

      Towards cracking the epigenetic code using a combination of high-throughput epigenomics and quantitative mass spectrometry-based proteomics (pages 547–551)

      Hendrik G. Stunnenberg and Michiel Vermeulen

      Article first published online: 24 MAY 2011 | DOI: 10.1002/bies.201100044

      Thumbnail image of graphical abstract

      High-throughput genomic sequencing and quantitative mass spectrometry were used simultaneously to study the biology of lysine trimethylations on the N-terminus of histone H3 and H4.

  7. Reports & Opinion

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. Book reviews

    2. Correspondence

      SMT vs. TOFT (page 555)

      Don A. Gilbert

      Article first published online: 1 JUN 2011 | DOI: 10.1002/bies.201100065

  8. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. You have free access to this content
  9. Biotec Visions

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. You have free access to this content
      Biotec Visions: BioEssays 7/2011

      Article first published online: 16 JUN 2011 | DOI: 10.1002/bies.201190034

  10. Next Issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Highlights from other journals
    6. Insights & Perspectives
    7. Prospects & Overviews
    8. Reports & Opinion
    9. Corrigendum
    10. Biotec Visions
    11. Next Issue
    1. You have free access to this content
      BioEssays – Next Issue

      Article first published online: 16 JUN 2011 | DOI: 10.1002/bies.201190035

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