Early eye development: Formation of the optic cup. Eye development is a complex process involving evagination and invagination processes of the retinal epithelium to form a double-walled cup structure. On pages 17–25 Eiraku et al. introduce a new model explaining the tissue dynamics that enable the spontaneous invagination of the neural retina. This “relaxation-expansion” model involves the following consecutive local rules: relaxation in the neural retina, apical constriction at the boundary epithelium between the neural retina and retinal pigment epithelium domains (hinge) and tangential expansion in the neural retina. Computer simulation of this model successfully recapitulates optic-cup morphogenesis.
Cover by M. Eiraku, T. Adachi and Y. Sasai.