BioEssays

Cover image for Vol. 34 Issue 2

February 2012

Volume 34, Issue 2

Pages 87–161

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Meetings
    8. BiotecVisions
    9. Next Issue
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      BioEssays 2/2012

      Version of Record online: 11 JAN 2012 | DOI: 10.1002/bies.201290002

      The ERK signalling pathway and Huntington's disease. On pages 142–148 Bodai and Marsh discuss the complexity of MAPK signaling in Huntington's disease. In this neurodegenerative disorder, mutant huntingtin protein can both activate or inhibit the MAP kinase ERK depending on the cell type and state. These actions can impact intercellular BDNF- and glutamate-signaling and other events that are transmitted through the ERK kinase pathway. Thus, pathogenic Htt can both activate and/or dampen different branches of the ERK cascade. Understanding the source of this complexity and ERK's key role in the pathogenic response may allow pharmacologic targeting that selectively enhances the protective branches of the ERK response for the treatment of this as yet incurable disease.

  2. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Meetings
    8. BiotecVisions
    9. Next Issue
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  3. Contents and highlights of this issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Meetings
    8. BiotecVisions
    9. Next Issue
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      BioEssays 2/2012 (pages 88–89)

      Version of Record online: 11 JAN 2012 | DOI: 10.1002/bies.201290001

  4. Insights & Perspectives

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Meetings
    8. BiotecVisions
    9. Next Issue
    1. Ideas & Speculations

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      How chromatin prevents genomic rearrangements: Locus colocalization induced by transcription factor binding (pages 90–93)

      Jérôme Déjardin

      Version of Record online: 16 NOV 2011 | DOI: 10.1002/bies.201100122

      Thumbnail image of graphical abstract

      The loosening of chromatin structures gives rise to unrestricted access to DNA and thus transcription factors (TFs) can bind to their otherwise masked target sequences. Regions bound by the same set of TFs tend to be located in close proximity and this might increase the probability of activating illegitimate genomic rearrangements.

    2. Think again

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    3. Commentary

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  5. Prospects & Overviews

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Meetings
    8. BiotecVisions
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    1. Review essays

      Wnt-Notch signalling: An integrated mechanism regulating transitions between cell states (pages 110–118)

      Silvia Muñoz-Descalzo, Joaquin de Navascues and Alfonso Martinez Arias

      Version of Record online: 3 JAN 2012 | DOI: 10.1002/bies.201100102

      Thumbnail image of graphical abstract

      There is significant interaction and cross talk between the Wnt and Notch signaling pathways during development and these pathways regulate the probability of transitions between cell states rather than directly controlling the transcriptional programs that determine the identity of a cell.

    2. On the opportunistic nature of transcription and replication initiation in the metazoan genome (pages 119–125)

      Joana Sequeira-Mendes and María Gómez

      Version of Record online: 16 NOV 2011 | DOI: 10.1002/bies.201100126

      Thumbnail image of graphical abstract

      The authors propose that replication origins cannot be defined as unique genomic features, but rather that DNA synthesis initiates opportunistically from accessible DNA sites, making cell highly robust and adaptable to environmental or developmental changes.

    3. Problems & Paradigms

      Shadow enhancers: Frequently asked questions about distributed cis-regulatory information and enhancer redundancy (pages 135–141)

      Scott Barolo

      Version of Record online: 15 NOV 2011 | DOI: 10.1002/bies.201100121

      Thumbnail image of graphical abstract

      The term “shadow enhancer” was coined rather recently and this article not only gives a revised definition of this term but also discusses possible mechanisms of shadow enhancer function and evolution.

    4. The molecular and mathematical basis of Waddington's epigenetic landscape: A framework for post-Darwinian biology? (pages 149–157)

      Sui Huang

      Version of Record online: 18 NOV 2011 | DOI: 10.1002/bies.201100031

      Thumbnail image of graphical abstract

      The straightforward causality implicit in one genotype leading to only one phenotype must nowadays be expanded to incorporate epigenetics, gene regulatory networks and gene expression noise.

  6. Meetings

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
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    8. BiotecVisions
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    1. Meetings

      Establishing a model organism: A report from the first annual Nematostella meeting (pages 158–161)

      Adam M. Reitzel, Joseph F. Ryan and Ann M. Tarrant

      Version of Record online: 18 NOV 2011 | DOI: 10.1002/bies.201100145

      Thumbnail image of graphical abstract

      The sea anemone Nematostella vectensis has developed into a model organism for studying genome evolution and animal development.

  7. BiotecVisions

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
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      BiotecVisions 2012, January (pages A1-A8)

      Version of Record online: 11 JAN 2012 | DOI: 10.1002/bies.201290003

  8. Next Issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. Meetings
    8. BiotecVisions
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      BioEssays – Next Issue

      Version of Record online: 11 JAN 2012 | DOI: 10.1002/bies.201290004

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