BioEssays

Cover image for Vol. 34 Issue 4

April 2012

Volume 34, Issue 4

Pages 253–327

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
    1. You have free access to this content
      BioEssays 4/2012

      Article first published online: 13 MAR 2012 | DOI: 10.1002/bies.201290013

      The Tasmanian devil is threatened by the incidence of a transmissible cancer (devil facial tumour disease, DFTD). On pages 285–292 Katherine Belov compares and contrasts this disease with canine transmissible venereal tumour (CTVT), focusing on the life histories of the clonal cell lines, their evolutionary trajectories and the mechanisms by which they have achieved immune tolerance. These two diseases provide unique models for understanding cancer biology and immunobiology, particularly the evolution of immune evasion strategies. Recently, whole-genome sequences of the Tasmanian devil, and of two distinct cancer subclones, have been published; these data provide further information about the pattern of evolution and spread of this parasitic clonal disease. Cover photo © melanieplusdaniel.de - Fotolia.com

  2. Editorial

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
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  3. Contents and highlights of this issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
    1. You have free access to this content
      BioEssays 4/2012 (pages 255–256)

      Article first published online: 13 MAR 2012 | DOI: 10.1002/bies.201290012

  4. Insights & Perspectives

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
    1. Idea to watch

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    2. Hypotheses

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      Excitable behavior can explain the “ping-pong” mode of communication between cells using the same chemoattractant (pages 259–266)

      Andrew B. Goryachev, Alexander Lichius, Graham D. Wright and Nick D. Read

      Article first published online: 23 JAN 2012 | DOI: 10.1002/bies.201100135

      Thumbnail image of graphical abstract

      Fusion of genetically identical cells in Neurospora crassa is achieved by the cells taking turns in releasing a chemoattractant and sensing it.

    3. Think again

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      MHC-dependent mate choice in humans: Why genomic patterns from the HapMap European American dataset support the hypothesis (pages 267–271)

      Romain Laurent and Raphaëlle Chaix

      Article first published online: 16 FEB 2012 | DOI: 10.1002/bies.201100150

      Thumbnail image of graphical abstract

      The MHC may influence mate choice in some human populations also depending on other variables such as socio-cultural factors, the level of genetic diversity and the strength of pathogenic pressures.

    4. Commentary

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      Biomarker development: Prudence, risk, and reproducibility (pages 277–279)

      Edward R. Dougherty

      Article first published online: 15 FEB 2012 | DOI: 10.1002/bies.201200003

      Thumbnail image of graphical abstract

      Is a two-fold approach — preliminary studies based on small samples followed by a large-sample study to check reproducibility — in the search for biomarkers really prudent?

  5. Prospects & Overviews

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
    1. Recently in press

      Beyond nutrients: Food-derived microRNAs provide cross-kingdom regulation (pages 280–284)

      Mengxi Jiang, Xiaolin Sang and Zhi Hong

      Article first published online: 22 FEB 2012 | DOI: 10.1002/bies.201100181

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      There is recent evidence that microRNAs derived from ingested food sources can be taken up, packaged into microvesicles and, upon reaching the final recipient cells, regulate a target gene in a sequence-specific manner.

    2. Review essays

      Contagious cancer: Lessons from the devil and the dog (pages 285–292)

      Katherine Belov

      Article first published online: 2 MAR 2012 | DOI: 10.1002/bies.201100161

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      A better understanding of the two known transmissible cancers (Tasmanian devil facial tumour and canine transmissible venereal tumour) may provide unique insights into the role of the immune system in shaping tumour evolution and may uncover novel approaches for treating human cancer.

    3. CREB signalling in neural stem/progenitor cells: Recent developments and the implications for brain tumour biology (pages 293–300)

      Theo Mantamadiotis, Nikos Papalexis and Sebastian Dworkin

      Article first published online: 13 FEB 2012 | DOI: 10.1002/bies.201100133

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      There is significant experimental data implicating the CREB signalling pathway in the development and maintenance of brain tumours, and this knowledge will provide an opportunity to investigate novel drug targeting approaches in glioma treatment.

    4. Balancing self-renewal and differentiation by asymmetric division: Insights from brain tumor suppressors in Drosophila neural stem cells (pages 301–310)

      Kai Chen Chang, Cheng Wang and Hongyan Wang

      Article first published online: 27 JAN 2012 | DOI: 10.1002/bies.201100090

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      Drosophila neuroblasts represent an excellent model system to study the molecular mechanisms of asymmetric divisions during stem cell self-renewal and how defects in this system lead to tumourigenesis.

    5. Problems & Paradigms

    6. Methods, Models & Techniques

      Visualizing and quantifying cell phenotype using soft X-ray tomography (pages 320–327)

      Gerry McDermott, Douglas M. Fox, Lindsay Epperly, Modi Wetzler, Annelise E. Barron, Mark A. Le Gros and Carolyn A. Larabell

      Article first published online: 30 JAN 2012 | DOI: 10.1002/bies.201100125

      Thumbnail image of graphical abstract

      Soft X-ray tomography is an imaging technique that can be used to visualize the internal architecture of fully hydrated, intact eukaryotic and prokaryotic cells at high spatial resolution.

  6. BiotecVisions

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
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      BiotecVisions 2012, March (pages A1-A8)

      Article first published online: 13 MAR 2012 | DOI: 10.1002/bies.201290014

  7. Next Issue

    1. Top of page
    2. Cover Picture
    3. Editorial
    4. Contents and highlights of this issue
    5. Insights & Perspectives
    6. Prospects & Overviews
    7. BiotecVisions
    8. Next Issue
    1. You have free access to this content
      BioEssays – Next Issue

      Article first published online: 13 MAR 2012 | DOI: 10.1002/bies.201290015

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