Replenishing our defensive microbes (pages 810–817)
Luke K. Ursell, William Van Treuren, Jessica L. Metcalf, Meg Pirrung, Andrew Gewirtz and Rob Knight
Version of Record online: 8 JUL 2013 | DOI: 10.1002/bies.201300018
Exposure to microbes is known to train our immune system to recognize pathogens and promote host health. Here, we discuss how modern behaviors, including Cesarean sections, antibiotic use, and limited exposure to animals, might derail our microbiota from its ancestral trajectory, and discuss suggested methods to replenish beneficial human microbes.