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Keywords:

  • Joint action of drugs;
  • Isobols;
  • Additivity;
  • Subadditivity;
  • Super-additivity;
  • Parametric alternatives to additivity

Abstract

The model of PLACKETT and HEWLETT (1963) for the joint action of mixtures of drugs in the case of quantal response is discussed in terms of isobols. The model is shown to be able to fit quite different types of joint actions.