Biometrical Journal

Cover image for Biometrical Journal

Special Issue: Adaptive Designs in Clinical Trials

August 2006

Volume 48, Issue 4

Pages 487–737

  1. Contents

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
    1. Contents: Biom. J. 4/2006 (pages 487–489)

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200690003

  2. Editorial

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
  3. Reviews

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
    1. Application of Adaptive Designs – a Review (pages 493–506)

      P. Bauer and J. Einfalt

      Version of Record online: 10 MAY 2006 | DOI: 10.1002/bimj.200510204

    2. An Overview of Statistical Approaches for Adaptive Designs and Design Modifications (pages 507–520)

      Helmut Schäfer, Nina Timmesfeld and Hans-Helge Müller

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200510234

    3. Some Aspects of the Application of Internal Pilot Studies (pages 556–557)

      Peter A. Lachenbruch and Janet Wittes

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610243

    4. Rejoinder (page 558)

      Tim Friede and Meinhard Kieser

      Version of Record online: 25 JUL 2006 | DOI: 10.1002/bimj.200610252

  4. Regulatory Perspectives

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
    1. A Regulatory View on Adaptive/Flexible Clinical Trial Design (pages 565–573)

      H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence

      Version of Record online: 13 JUN 2006 | DOI: 10.1002/bimj.200610229

    2. Opening the Adaptive Toolbox (pages 598–603)

      Janet Wittes and Peter A. Lachenbruch

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610240

    3. Rejoinder (pages 613–615)

      H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610258

    4. Rejoinder (pages 616–622)

      Armin Koch

      Version of Record online: 25 JUL 2006 | DOI: 10.1002/bimj.200610251

  5. Seamless Trials

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
    1. Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: General Concepts (pages 623–634)

      Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer

      Version of Record online: 25 JUL 2006 | DOI: 10.1002/bimj.200510232

    2. Rejoinder (pages 660–662)

      Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610255

  6. New Developments

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
    1. An Adaptive Hierarchical Test Procedure for Selecting Safe and Efficient Treatments (pages 663–678)

      Franz König, Peter Bauer and Werner Brannath

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200510235

    2. Combining Treatment Selection and Definitive Testing (pages 690–692)

      Michael A. Proschan and Sally A. Hunsberger

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610247

    3. Rejoinder (pages 693–694)

      Franz König, Peter Bauer and Werner Brannath

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610256

    4. Rejoinder (pages 695–696)

      Jixian Wang

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200510254

    5. Adaptive vs. Group Sequential Self-designing Trials (pages 710–712)

      Devan V. Mehrotra and Xiaoyin (Frank) Fan

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610259

    6. Rejoinder (page 713)

      Joachim Hartung and Guido Knapp

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200610253

  7. Software

    1. Top of page
    2. Contents
    3. Editorial
    4. Reviews
    5. Regulatory Perspectives
    6. Seamless Trials
    7. New Developments
    8. Software
    1. A Brief Review on Software Developments for Group Sequential and Adaptive Designs (pages 732–737)

      Gernot Wassmer and Marc Vandemeulebroecke

      Version of Record online: 8 AUG 2006 | DOI: 10.1002/bimj.200510233

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