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Despite extensive evidence of significant and pervasive impairments in communication in individuals with Down syndrome, there is relatively little empirical and behavior analytic research demonstrating effective intervention procedures. In this study, we examined a behavior analytic intervention to teach answers to questions in two children with Down syndrome. Children acquired the target responses and generalized across settings and people. This contributes to the growing body of demonstrations of behavior analytic interventions to address the needs of children with Down syndrome. Copyright © 2013 John Wiley & Sons, Ltd.