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Free radical scavenging abilities of flavonyl-thiazolidine-2,4-dione compounds

Authors

  • Oya Bozdağ-Dündar,

    1. Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandoğan, Ankara, Turkey
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  • Rahmiye Ertan,

    1. Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandoğan, Ankara, Turkey
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  • Hassan Y. Aboul-Enein,

    Corresponding author
    1. Pharmaceutical and Medicinal Chemistry Department, The Pharmacetical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, Egypt
    • Pharmaceutical and Medicinal Chemistry Department, The Pharmacetical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, Egypt
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  • Aleksandra Kładna,

    1. Department of Medical History and Ethics, Pomeranian Medical Academy, ul. Rybacka 1, 70-204 Szczecin, Poland
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  • Irena Kruk

    1. Institute of Physics, West Pomeranian University of Technology, Szczecin, Al. Piastów 48/49, 70-311 Szczecin, Poland
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Abstract

Free radical scavenging activity of flavonyl-thiazolidine-2,4-dione compounds has been evaluated using chemiluminescence, electron spin resonance spectroscopy with 5,5-dimethyl-1-pyrroline-1-oxide as spin trap and DPPH (2,2′-diphenyl-1-picrylhydrazyl) method. The examined compounds exhibited 28–50% scavenging superoxide anion radical (equation image), 16.7–76.7% hydroxyl radical (HO) and 9–40% DPPH radical. Compounds containing carbonyl group in their structure can be considered as antioxidants with high relevance and great biological importance. Copyright © 2009 John Wiley & Sons, Ltd.

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