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COX-2 in the neurodegenerative process of Parkinson's disease†
Article first published online: 23 JUL 2012
Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.
Volume 38, Issue 6, pages 395–397, November/December 2012
How to Cite
Teismann, P. (2012), COX-2 in the neurodegenerative process of Parkinson's disease. BioFactors, 38: 395–397. doi: 10.1002/biof.1035
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
- Issue published online: 14 DEC 2012
- Article first published online: 23 JUL 2012
- Manuscript Accepted: 12 JUN 2012
- Manuscript Received: 24 APR 2012
- Wellcome Trust. Grant Number: WT080782MF
- NHS Endowment fund. Grant Number: 06-09
- Parkinson's disease;
The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase—cyclooxygenase and peroxidase activity. © 2012 International Union of Biochemistry and Molecular Biology, Inc.