Original Article

Positive correlation between maternal serum coenzyme Q10 levels and infant birth weight

  1. Megumi Haruna1,†,*,
  2. Masayo Matsuzaki1,
  3. Erika Ota1,
  4. Yuka Honda1,
  5. Takashi Tanizaki2,
  6. Kyoichi Sekine2,
  7. Nobuyuki Tabata3,
  8. SeonAe Yeo4,
  9. Sachiyo Murashima5

Article first published online: 16 JUL 2010

DOI: 10.1002/biof.104

Issue

BioFactors

BioFactors

Volume 36, Issue 4, pages 312–318, July/August 2010

Additional Information

How to Cite

Haruna, M., Matsuzaki, M., Ota, E., Honda, Y., Tanizaki, T., Sekine, K., Tabata, N., Yeo, S. and Murashima, S. (2010), Positive correlation between maternal serum coenzyme Q10 levels and infant birth weight. BioFactors, 36: 312–318. doi: 10.1002/biof.104

Author Information

  1. 1

    Department of Midwifery and Women's Health, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  2. 2

    IVD Development Department, Mitsubishi Chemical Medience Corporation, Chiba, Japan

  3. 3

    Sanwa Kagaku Kenkyusho Co., Ltd., Aichi, Japan

  4. 4

    School of Nursing, The University of North Carolina, Chapel Hill, North Carolina, USA

  5. 5

    Department of Community Health Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  1. †

    Tel & Fax: 81-3-5841-3396

*Department of Midwifery and Women's Health, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Publication History

  1. Issue published online: 16 AUG 2010
  2. Article first published online: 16 JUL 2010
  3. Manuscript Accepted: 16 MAY 2010
  4. Manuscript Received: 29 AUG 2009

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Keywords:

  • antioxidant;
  • birth weight;
  • coenzyme Q10;
  • fat mass;
  • pregnancy

Abstract

The purpose of this study was to examine the relationship between the level of maternal serum coenzyme Q10 (CoQ10), which is a lipid-soluble antioxidant, maternal body weight gain, fat mass gain, and infant birth weight. A longitudinal observational study was conducted with 50 healthy pregnant women (average age: 31.1 years, average body mass index (BMI): 21.3 kg/m2 at prepregnancy) at each trimester. CoQ10 levels were measured by high performance liquid chromatography. Maternal weight and body composition were measured by a bioelectrical impedance analysis. The CoQ10 levels significantly increased throughout pregnancy from the first trimester to the third trimester (P < 0.001), and correlated with not only the serum cholesterol levels (P < 0.01) but also with the serum acetoacetic acid levels (P < 0.05) in the third trimester. The CoQ10 levels correlated with the maternal weight gain (P < 0.05) and fat mass gain (P < 0.05) from the second to the third trimester, after adjusting for lipid markers, age, and smoking habits. The level of CoQ10 during the third trimester was also significantly associated with the infant birth weight (P < 0.05) after adjusting for gestational age, maternal prepregnancy BMI, and smoking habits. Therefore, it is concluded that the level of maternal CoQ10 is positively associated with fetal growth, balancing rapid metabolic changes in the last half of a normal pregnancy.

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