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Curcumin and liver disease

Authors

  • Laura Vera-Ramirez,

    1. GENyO Center Pfizer-University of Granada & Andalusian Government Centre for Genomics & Oncology, Granada, Spain
    2. Department of Oncology, Complejo Hospitalario de Jaen, Jaen, Spain
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  • Patricia Pérez-Lopez,

    1. Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Physiology, University of Granada, Granada, Spain
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  • Alfonso Varela-Lopez,

    1. Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Physiology, University of Granada, Granada, Spain
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  • MCarmen Ramirez-Tortosa,

    1. Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
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  • Maurizio Battino,

    1. Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy
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  • José L. Quiles

    Corresponding author
    1. Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Physiology, University of Granada, Granada, Spain
    • Instituto de Nutrición y Tecnología de los Alimentos “José Mataix Verdú”, Universidad de Granada, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Lab. 120, Avenida del Conocimiento s/n, 18071 Granada, Spain
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    • Tel.:+34 958241000, Ext. 20316; Fax:+34 958241000 Ext. 20316


Abstract

Liver diseases pose a major medical problem worldwide and a wide variety of herbs have been studied for the management of liver-related diseases. In this respect, curcumin has long been used in traditional medicine, and in recent years it has been the object of increasing research interest. In combating liver diseases, it seems clear that curcumin exerts a hypolipidic effect, which prevents the fatty acid accumulation in the hepatocytes that may result from metabolic imbalances, and which may cause nonalcoholic steatohepatitis. Another crucial protective activity of curcumin, not only in the context of chronic liver diseases but also regarding carcinogenesis and other age-related processes, is its potent antioxidant activity, which affects multiple processes and signaling pathways. The effects of curcumin on NF-κβ are crucial to our understanding of the potent hepatoprotective role of this herb-derived micronutrient. Because curcumin is a micronutrient that is closely related to cellular redox balance, its properties and activity give rise to a series of molecular reactions that in every case and biological situation affect the mitochondria. © 2013 BioFactors, 39(1):88–100, 2013

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