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Skin regenerative potentials of curcumin

  1. Rajesh L. Thangapazham1,†,*,
  2. Shashwat Sharad2,
  3. Radha K. Maheshwari3

Article first published online: 11 JAN 2013

DOI: 10.1002/biof.1078

Issue

BioFactors

BioFactors

Special Issue: CURCUMIN

Volume 39, Issue 1, pages 141–149, January/February 2013

Additional Information

How to Cite

Thangapazham, R. L., Sharad, S. and Maheshwari, R. K. (2013), Skin regenerative potentials of curcumin. BioFactors, 39: 141–149. doi: 10.1002/biof.1078

Author Information

  1. 1

    Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

  2. 2

    Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

  3. 3

    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

  1. †

    Tel.: 301-295-3820; Fax: 3-1-295-3566

*Ph.D., Department of Dermatology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA

  1. †

    Tel.: 301-295-3820; Fax: 3-1-295-3566

Publication History

  1. Issue published online: 19 FEB 2013
  2. Article first published online: 11 JAN 2013
  3. Manuscript Accepted: 29 NOV 2012
  4. Manuscript Received: 29 OCT 2012

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Keywords:

  • curcumin;
  • skin regeneration;
  • anticancer;
  • wound healing;
  • chemoprevention

Abstract

Curcumin, an active constituent of the spice turmeric, is well known for its chemopreventive properties and is found to be beneficial in treating various disorders including skin diseases. Curcumin protects skin by quenching free radicals and reducing inflammation through the inhibition of nuclear factor-kappa B. Curcumin also affects other signaling pathways including transforming growth factor-β and mitogen-activated protein kinase pathway. Curcumin also modulates the phase II detoxification enzymes which are crucial in detoxification reactions and for protection against oxidative stress. In the present review, the biological mechanisms of the chemopreventive potential of curcumin in various skin diseases like psoriasis, vitiligo, and melanoma is discussed. The application of curcumin in skin regeneration and wound healing is also elucidated. We also explored the recent innovations and advances involved in the development of transdermal delivery systems to enhance the bioavailability of curcumin, particularly in the skin. Recent clinical trials pertaining to the use of curumin in skin diseases establishes its benefits and also the need for additional clinical trials in other diseases are discussed. © 2013 BioFactors, 39(1):141–149, 2013

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