SEARCH

SEARCH BY CITATION

References

  • 1
    Fubini, B. (1997) Surface reactivity in the pathogenic response to particulates. Environ. Health Perspect. 105, 10131020.
  • 2
    Shio, M. T., Kassa, F. A., Bellemare, M. J., and Olivier, M. (2010) Innate inflammatory response to the malarial pigment hemozoin. Microbes Infect. 12, 889899.
  • 3
    Hanscheid, T., Egan, T. J., and Grobusch, M. P. (2007) Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator. Lancet Infect. Dis. 7, 675685.
  • 4
    Arese, P. and Schwarzer, E. (1997) Malarial pigment (haemozoin): a very active ‘inert’ substance. Ann. Trop. Med. Parasitol. 91, 501516.
  • 5
    Amodu, O. K., Adeyemo, A. A., Olumese, P. E., and Gbadegesin, R. A. (1998) Intraleukocytic malaria pigment and clinical severity of malaria in children. Trans. R. Soc. Trop. Med. Hyg. 92, 5456.
  • 6
    Taylor, T. E., Fu, W. J., Carr, R. A., Whitten, R. O., Mueller, J. S., et al. (2004) Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat. Med. 10, 143145.
  • 7
    Busso, N. and So, A. (2010) Mechanisms of inflammation in gout. Arthritis Res. Ther. 12, 206.
  • 8
    Kamp, D. W. and Weitzman, S. A. (1999) The molecular basis of asbestos induced lung injury. Thorax 54, 638652.
  • 9
    Richette, P. and Bardin, T. (2010) Gout. Lancet 375, 318328.
  • 10
    Dalbeth, N. and Haskard, D. O. (2005) Mechanisms of inflammation in gout. Rheumatology (Oxford, U.K.) 44, 10901096.
  • 11
    Rom, W. N., Travis, W. D., and Brody, A. R. (1991) Cellular and molecular basis of the asbestos-related diseases. Am. Rev. Respir. Dis. 143, 408422.
  • 12
    Jaramillo, M., Bellemare, M. J., Martel, C., Shio, M. T., Contreras, A. P., et al. (2009) Synthetic Plasmodium-like hemozoin activates the immune response: a morphology–function study. PLoS One 4, e6957.
  • 13
    Shi, Y., Evans, J. E., and Rock, K. L. (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516521.
  • 14
    Pisciotta, J. M., Ponder, E. L., Fried, B., and Sullivan, D. (2005) Hemozoin formation in Echinostoma trivolvis rediae. Int. J. Parasitol. 35, 10371042.
  • 15
    Desai, M., ter Kuile, F. O., Nosten, F., McGready, R., Asamoa, K., et al. (2007) Epidemiology and burden of malaria in pregnancy. Lancet Infect. Dis. 7, 93104.
  • 16
    Biswas, S., Karmarkar, M. G., and Sharma, Y. D. (2001) Antibodies detected against Plasmodium falciparum haemozoin with inhibitory properties to cytokine production. FEMS Microbiol. Lett. 194, 175179.
  • 17
    Terkeltaub, R., Tenner, A. J., Kozin, F., and Ginsberg, M. H. (1983) Plasma protein binding by monosodium urate crystals. Analysis by two-dimensional gel electrophoresis. Arthritis Rheum. 26, 775783.
  • 18
    Martinon, F. (2010) Mechanisms of uric acid crystal-mediated autoinflammation. Immunol. Rev. 233, 218232.
  • 19
    Deroost, K., Tyberghein, A., Lays, N., Noppen, S., Schwarzer, E., et al. (2013) Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome. Am. J. Respir. Cell Mol. Biol. 48, 589600.
  • 20
    Choi, H. K., Atkinson, K., Karlson, E. W., Willett, W., and Curhan, G. (2004) Purine-rich foods, dairy and protein intake, and the risk of gout in men. N. Engl. J. Med. 350, 10931103.
  • 21
    Rubenstein, J. and Pritzker, K. P. (1989) Crystal-associated arthropathies. Am. J. Roentgenol. 152, 685695.
  • 22
    Tweedale, G. (2002) Asbestos and its lethal legacy. Nat. Rev. Cancer 2, 311315.
  • 23
    Chen, M. M., Shi, L., and Sullivan, D. J., Jr. (2001) Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and β-hematin. Mol. Biochem. Parasitol. 113, 18.
  • 24
    Oliveira, M. F., Silva, J. R., Dansa-Petretski, M., de Souza, W., Lins, U., et al. (1999) Haem detoxification by an insect. Nature 400, 517518.
  • 25
    Doolan, D. L., Dobano, C., and Baird, J. K. (2009) Acquired immunity to malaria. Clin. Microbiol. Rev. 22, 1336.
  • 26
    Mossman, B. T. and Churg, A. (1998) Mechanisms in the pathogenesis of asbestosis and silicosis. Am. J. Respir. Crit. Care Med. 157, 16661680.
  • 27
    Schofield, L. and Grau, G. E. (2005) Immunological processes in malaria pathogenesis. Nat. Rev. Immunol. 5, 722735.
  • 28
    Tuteja, R. (2007) Malaria—an overview. FEBS J. 274, 46704679.
  • 29
    Krugliak, M., Zhang, J., and Ginsburg, H. (2002) Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins. Mol. Biochem. Parasitol. 119, 249256.
  • 30
    Egan, T. J. (2008) Haemozoin formation. Mol. Biochem. Parasitol. 157, 127136.
  • 31
    Goldberg, D. E. (2005) Hemoglobin degradation. Curr. Top. Microbiol. Immunol. 295, 275291.
  • 32
    Pisciotta, J. M. and Sullivan, D. (2008) Hemozoin: oil versus water. Parasitol. Int. 57, 8996.
  • 33
    Pagola, S., Stephens, P. W., Bohle, D. S., Kosar, A. D., and Madsen, S. K. (2000) The structure of malaria pigment β-haematin. Nature. 404, 307310.
  • 34
    Schwarzer, E., De Matteis, F., Giribaldi, G., Ulliers, D., Valente, E., et al. (1999) Hemozoin stability and dormant induction of heme oxygenase in hemozoin-fed human monocytes. Mol. Biochem. Parasitol. 100, 6172.
  • 35
    Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., et al. (2008) HDP—a novel heme detoxification protein from the malaria parasite. PLoS Pathog. 4, e1000053.
  • 36
    Pisciotta, J. M., Coppens, I., Tripathi, A. K., Scholl, P. F., Shuman, J., et al. (2007) The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization. Biochem. J. 402, 197204.
  • 37
    Hoang, A. N., Sandlin, R. D., Omar, A., Egan, T. J., and Wright, D. W. (2010) The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy. Biochemistry 49, 1010710116.
  • 38
    Hoang, A. N., Ncokazi, K. K., De Villiers, K. A., Wright, D. W., and Egan, T. J. (2010) Crystallization of synthetic haemozoin (β-haematin) nucleated at the surface of lipid particles. Dalton Trans. 39, 12351244.
  • 39
    Kapishnikov, S., Weiner, A., Shimoni, E., Guttmann, P., Schneider, G., et al. (2012) Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 109, 1118811193.
  • 40
    Gligorijevic, B., McAllister, R., Urbach, J. S., and Roepe, P. D. (2006) Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. I. Quantification of hemozoin development for drug sensitive versus resistant malaria. Biochemistry 45, 1240012410.
  • 41
    Dasari, P., Heber, S. D., Beisele, M., Torzewski, M., Reifenberg, K., et al. (2012) Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation. Blood 119, 43014310.
  • 42
    Stanley, H. A., Langreth, S. G., Reese, R. T., and Trager, W. (1982) Plasmodium falciparum merozoites: isolation by density gradient centrifugation using Percoll and antigenic analysis. J. Parasitol. 68, 10591067.
  • 43
    Clavijo, C. A., Mora, C. A., and Winograd, E. (1998) Identification of novel membrane structures in Plasmodium falciparum infected erythrocytes. Mem. Inst. Oswaldo Cruz. 93, 115120.
  • 44
    Coban, C., Ishii, K. J., Uematsu, S., Arisue, N., Sato, S., et al. (2007) Pathological role of Toll-like receptor signaling in cerebral malaria. Int. Immunol. 19, 6779.
  • 45
    Deroost, K., Lays, N., Noppen, S., Martens, E., Opdenakker, G., et al. (2012) Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice. Malar. J. 11, 166.
  • 46
    Sherry, B. A., Alava, G., Tracey, K. J., Martiney, J., Cerami, A., et al. (1995) Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1α, and MIP-1β) in vitro, and altered thermoregulation in vivo. J. Inflamm. 45, 8596.
  • 47
    Schwarzer, E., Kuhn, H., Valente, E., and Arese, P. (2003) Malaria-parasitized erythrocytes and hemozoin nonenzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions. Blood 101, 722728.
  • 48
    Parroche, P., Lauw, F. N., Goutagny, N., Latz, E., Monks, B. G., et al. (2007) Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc. Natl. Acad. Sci. USA 104, 19191924.
  • 49
    Prato, M., Gallo, V., Giribaldi, G., Aldieri, E., and Arese, P. (2010) Role of the NF-кB transcription pathway in the haemozoin- and 15-HETE-mediated activation of matrix metalloproteinase-9 in human adherent monocytes. Cell Microbiol. 12, 17801791.
  • 50
    Khadjavi, A., Valente, E., Giribaldi, G., and Prato, M. Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes. Cell Biochem. Funct., in press.
  • 51
    Schwarzer, E., Bellomo, G., Giribaldi, G., Ulliers, D., and Arese, P. (2001) Phagocytosis of malarial pigment haemozoin by human monocytes: a confocal microscopy study. Parasitology 123, 125131.
  • 52
    Griffith, J. W., Sun, T., McIntosh, M. T., and Bucala, R. (2009) Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J. Immunol. 183, 52085220.
  • 53
    Schwarzer, E., Turrini, F., Ulliers, D., Giribaldi, G., Ginsburg, H., et al. (1992) Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. J. Exp. Med. 176, 10331041.
  • 54
    Paul, H., Reginato, A. J., and Schumacher, H. R. (1983) Morphological characteristics of monosodium urate: a transmission electron microscopic study of intact natural and synthetic crystals. Ann. Rheum. Dis. 42, 7581.
  • 55
    Schwarzer, E., Alessio, M., Ulliers, D., and Arese, P. (1998) Phagocytosis of the malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytes. Infect. Immun. 66, 16011606.
  • 56
    Schwarzer, E., Turrini, F., Giribaldi, G., Cappadoro, M., and Arese, P. (1993) Phagocytosis of P. falciparum malarial pigment hemozoin by human monocytes inactivates monocyte protein kinase C. Biochim. Biophys. Acta 1181, 5154.
  • 57
    Schwarzer, E. and Arese, P. (1996) Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages. Biochim. Biophys. Acta 1316, 169175.
  • 58
    Skorokhod, O. A., Alessio, M., Mordmuller, B., Arese, P., and Schwarzer, E. (2004) Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-γ-mediated effect. J. Immunol. 173, 40664074.
  • 59
    Giribaldi, G., Prato, M., Ulliers, D., Gallo, V., Schwarzer, E., et al. (2010) Involvement of inflammatory chemokines in survival of human monocytes fed with malarial pigment. Infect. Immun. 78, 49124921.
  • 60
    Noland, G. S., Briones, N., and Sullivan, D. J. (2003) The shape and size of hemozoin crystals distinguishes diverse Plasmodium species. Mol. Biochem. Parasitol. 130, 9199.
  • 61
    Kassa, F. A., Shio, M. T., Bellemare, M. J., Faye, B., Ndao, M., et al. (2011) New inflammation-related biomarkers during malaria infection. PLoS One 6, e26495.
  • 62
    Kamp, D. W. (2009) Asbestos-induced lung diseases: an update. Transl. Res. 153, 143152.
  • 63
    Coban, C., Igari, Y., Yagi, M., Reimer, T., Koyama, S., et al. (2010) Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe. 7, 5061.
  • 64
    Shio, M. T., Eisenbarth, S. C., Savaria, M., Vinet, A. F., Bellemare, M. J., et al. (2009) Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 5, e1000559.
  • 65
    Scorza, T., Magez, S., Brys, L., and De Baetselier, P. (1999) Hemozoin is a key factor in the induction of malaria-associated immunosuppression. Parasite Immunol. 21, 545554.
  • 66
    Jaramillo, M., Gowda, D. C., Radzioch, D., and Olivier, M. (2003) Hemozoin increases IFN-γ-inducible macrophage nitric oxide generation through extracellular signal-regulated kinase- and NF-кB-dependent pathways. J. Immunol. 171, 42434253.
  • 67
    Coban, C., Ishii, K. J., Sullivan, D. J., and Kumar, N. (2002) Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine. Infect. Immun. 70, 39393943.
  • 68
    Dasari, P., Reiss, K., Lingelbach, K., Baumeister, S., Lucius, R., et al. (2011) Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes. Blood 118, 49464956.
  • 69
    Coban, C., Ishii, K. J., Kawai, T., Hemmi, H., Sato, S., et al. (2005) Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201, 1925.
  • 70
    Carney, C. K., Schrimpe, A. C., Halfpenny, K., Harry, R. S., Miller, C. M., et al. (2006) The basis of the immunomodulatory activity of malaria pigment (hemozoin). J. Biol. Inorg. Chem. 11, 917929.
  • 71
    Dostert, C., Guarda, G., Romero, J. F., Menu, P., Gross, O., et al. (2009) Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 4, e6510.
  • 72
    Jaramillo, M., Godbout, M., and Olivier, M. (2005) Hemozoin induces macrophage chemokine expression through oxidative stress-dependent and -independent mechanisms. J. Immunol. 174, 475484.
  • 73
    Jaramillo, M., Plante, I., Ouellet, N., Vandal, K., Tessier, P. A., et al. (2004) Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection. J. Immunol. 172, 31013110.
  • 74
    Keller, C. C., Yamo, O., Ouma, C., Ong'echa, J. M., Ounah, D., et al. (2006) Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia. Infect. Immun. 74, 52495260.
  • 75
    Roddy, E. and Doherty, M. (2010) Epidemiology of gout. Arthritis Res. Ther. 12, 223.
  • 76
    McGill, N. W., Hayes, A., and Dieppe, P. A. (1992) Morphological evidence for biological control of urate crystal formation in vivo and in vitro. Scand. J. Rheumatol. 21, 215219.
  • 77
    Sanchez, V. C., Pietruska, J. R., Miselis, N. R., Hurt, R. H., and Kane, A. B. (2009) Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 1, 511529.
  • 78
    Ross, M., Langer, A. M., Nord, G. L., Nolan, R. P., Lee, R. J., et al. (2008) The mineral nature of asbestos. Regul. Toxicol. Pharmacol. 52, S26S30.
  • 79
    Stayner, L., Welch, L. S., and Lemen, R. (2013) The worldwide pandemic of asbestos-related diseases. Annu. Rev. Public Health 34, 205216.
  • 80
    O'Reilly, K. M., McLaughlin, A. M., Beckett, W. S., and Sime, P. J. (2007) Asbestos-related lung disease. Am. Fam. Physician 75, 683688.
  • 81
    Saint-Remy, J. M. and Cole, P. (1980) Interactions of chrysotile asbestos fibres with the complement system. Immunology 41, 431437.
  • 82
    Liu-Bryan, R., Scott, P., Sydlaske, A., Rose, D. M., and Terkeltaub, R. (2005) Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 52, 29362946.
  • 83
    Ng, G., Sharma, K., Ward, S. M., Desrosiers, M. D., Stephens, L. A., et al. (2008) Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29, 807818.
  • 84
    Martinon, F., Petrilli, V., Mayor, A., Tardivel, A., and Tschopp, J. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237241.
  • 85
    Cassel, S. L., Eisenbarth, S. C., Iyer, S. S., Sadler, J. J., Colegio, O. R., et al. (2008) The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl. Acad. Sci. USA 105, 90359040.
  • 86
    Palomaki, J., Valimaki, E., Sund, J., Vippola, M., Clausen, P. A., et al. (2011) Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5, 68616870.
  • 87
    Hill, I. M., Beswick, P. H., and Donaldson, K. (1996) Enhancement of the macrophage oxidative burst by immunoglobulin coating of respirable fibers: fiber-specific differences between asbestos and man-made fibers. Exp. Lung Res. 22, 133148.
  • 88
    Shirahama, T. and Cohen, A. S. (1974) Ultrastructural evidence for leakage of lysosomal contents after phagocytosis of monosodium urate crystals. A mechanism of gouty inflammation. Am. J. Pathol. 76, 501520.
  • 89
    Liu, G., Beri, R., Mueller, A., and Kamp, D. W. (2010) Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis. Chem. Biol. Interact. 188, 309318.
  • 90
    Levesque, M. A., Sullivan, A. D., and Meshnick, S. R. (1999) Splenic and hepatic hemozoin in mice after malaria parasite clearance. J. Parasitol. 85, 570573.
  • 91
    Frita, R., Carapau, D., Mota, M. M., and Hanscheid, T. (2012) In vivo hemozoin kinetics after clearance of Plasmodium berghei infection in mice. Malar. Res. Treat. 2012, 373086.
  • 92
    Barrera, V., Skorokhod, O. A., Baci, D., Gremo, G., Arese, P., et al. (2011) Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action. Blood 117, 56745682.
  • 93
    Shi, Y., Mucsi, A. D., and Ng, G. (2010) Monosodium urate crystals in inflammation and immunity. Immunol. Rev. 233, 203217.
  • 94
    Hasselbacher, P. (1979) Binding of immunoglobulin and activation of complement by asbestos fibers. J. Allergy Clin. Immunol. 64, 294298.
  • 95
    Dostert, C., Petrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., et al. (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674677.
  • 96
    Glushakova, S., Yin, D., Li, T., and Zimmerberg, J. (2005) Membrane transformation during malaria parasite release from human red blood cells. Curr. Biol. 15, 16451650.
  • 97
    Abkarian, M., Massiera, G., Berry, L., Roques, M., and Braun-Breton, C. (2011) A novel mechanism for egress of malarial parasites from red blood cells. Blood 117, 41184124.
  • 98
    Liu, R., O'Connell, M., Johnson, K., Pritzker, K., Mackman, N., et al. (2000) Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor кB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis Rheum. 43, 11451155.
  • 99
    Jaramillo, M., Naccache, P. H., and Olivier, M. (2004) Monosodium urate crystals synergize with IFN-γ to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-кB. J. Immunol. 172, 57345742.
  • 100
    Jaramillo, M., Godbout, M., Naccache, P. H., and Olivier, M. (2004) Signaling events involved in macrophage chemokine expression in response to monosodium urate crystals. J. Biol. Chem. 279, 5279752805.
  • 101
    Tephly, L. A. and Carter, A. B. (2008) Asbestos-induced MKP-3 expression augments TNF-α gene expression in human monocytes. Am. J. Respir. Cell Mol. Biol. 39, 113123.
  • 102
    Pouliot, M., James, M. J., McColl, S. R., Naccache, P. H., and Cleland, L. G. (1998) Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes. Blood 91, 17691776.
  • 103
    Skorokhod, O., Schwarzer, E., Grune, T., and Arese, P. (2005) Role of 4-hydroxynonenal in the hemozoin-mediated inhibition of differentiation of human monocytes to dendritic cells induced by GM-CSF/IL-4. Biofactors 24, 283289.
  • 104
    Schwarzer, E., Muller, O., Arese, P., Siems, W. G., and Grune, T. (1996) Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. A possible clue for hemozoin toxicity. FEBS Lett. 388, 119122.
  • 105
    Tschopp, J. and Schroder, K. (2010) NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat. Rev. Immunol. 10, 210215.
  • 106
    Mordmuller, B., Turrini, F., Long, H., Kremsner, P. G., and Arese, P. (1998) Neutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production. Eur. Cytokine Netw. 9, 239245.
  • 107
    Skorokhod, O. A., Schwarzer, E., Ceretto, M., and Arese, P. (2007) Malarial pigment haemozoin, IFN-γ, TNF-α, IL-1β and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes. Malar. J. 6, 73.
  • 108
    Ismail, M. R., Ordi, J., Menendez, C., Ventura, P. J., Aponte, J. J., et al. (2000) Placental pathology in malaria: a histological, immunohistochemical, and quantitative study. Hum. Pathol. 31, 8593.
  • 109
    Cunnington, A. J., De Souza, J. B., Walther, M., and Riley, E. M. (2012) Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nat. Med. 18, 120127.
  • 110
    Schroder, K. and Tschopp, J. (2010) The inflammasomes. Cell 140, 821832.
  • 111
    Orengo, J. M., Evans, J. E., Bettiol, E., Leliwa-Sytek, A., Day, K., et al. (2008) Plasmodium-induced inflammation by uric acid. PLoS Pathog. 4, e1000013.
  • 112
    Lopera-Mesa, T. M., Mita-Mendoza, N. K., Van de Hoef, D. L., Doumbia, S., Konate, D., et al. (2012) Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. PLoS One 7, e46424.
  • 113
    van de Hoef, D. L., Coppens, I., Holowka, T., Ben Mamoun, C., Branch, O., et al. (2013) Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells. PLoS One 8, e55584.
  • 114
    Shukla, A., Stern, M., Lounsbury, K. M., Flanders, T., and Mossman, B. T. (2003) Asbestos-induced apoptosis is protein kinase C delta-dependent. Am. J. Respir. Cell Mol. Biol. 29, 198205.
  • 115
    Liu-Bryan, R., Pritzker, K., Firestein, G. S., and Terkeltaub, R. (2005) TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J. Immunol. 174, 50165023.
  • 116
    Underhill, D. M. and Goodridge, H. S. (2007) The many faces of ITAMs. Trends Immunol. 28, 6673.
  • 117
    Su, B. and Karin, M. (1996) Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8, 402411.
  • 118
    Hsieh, M. S., Ho, H. C., Chou, D. T., Pan, S., Liang, Y. C., et al. (2003) Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages. J. Cell Biochem. 89, 791799.
  • 119
    Liu, R., Liote, F., Rose, D. M., Merz, D., and Terkeltaub, R. (2004) Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum. 50, 247258.
  • 120
    McMillan, R. M., Vater, C. A., Hasselbacher, P., Hahn, J., and Harris, E. D., Jr. (1981) Induction of collagenase and prostaglandin synthesis in synovial fibroblasts treated with monosodium urate crystals. J. Pharm. Pharmacol. 33, 382383.
  • 121
    Luty, A. J., Perkins, D. J., Lell, B., Schmidt-Ott, R., Lehman, L. G., et al. (2000) Low interleukin-12 activity in severe Plasmodium falciparum malaria. Infect. Immun. 68, 39093915.
  • 122
    Punsawad, C., Krudsood, S., Maneerat, Y., Chaisri, U., Tangpukdee, N., et al. (2012) Activation of nuclear factor кB in peripheral blood mononuclear cells from malaria patients. Malar. J. 11, 191.
  • 123
    Millington, O. R., Di Lorenzo, C., Phillips, R. S., Garside, P., and Brewer, J. M. (2006) Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function. J. Biol. 5, 5.
  • 124
    Urban, B. C. and Todryk, S. (2006) Malaria pigment paralyzes dendritic cells. J. Biol. 5, 4.
  • 125
    Deroost, K., Lays, N., Baci, D., Komuta, M., Prato, M., et al. Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain, submitted.