Novel insights on interactions between folate and lipid metabolism

Authors

  • Robin P. da Silva,

    1. Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
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  • Karen B. Kelly,

    1. Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
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  • Ala Al Rajabi,

    1. Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
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  • René L. Jacobs

    Corresponding author
    1. Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    • Address for correspondence: René L. Jacobs, Ph.D., Department of Agricultural, Food & Nutritional Science, 4-002 Li Ka Shing (LKS) Centre for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2E1, Canada. Fax: +780-492-9270; E-mail: rjacobs@ualberta.ca.

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Abstract

Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation. The liver is responsible for many methylation reactions that are used for post-translational modification of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phosphatidylcholine synthesis resulting in non-alcoholic fatty liver disease and steatohepatitis. In addition, folate intake and folate status have been associated with changes in the expression of genes involved in lipid metabolism, obesity, and metabolic syndrome. In this review, we provide insight on the relationship between folate and lipid metabolism, and an outlook for the future of lipid-related folate research. © 2013 BioFactors, 40(3):277–283, 2014

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