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Keywords:

  • N-arachidonoyl serine;
  • N-arachidonoyl glycine;
  • N-acyl taurines;
  • N-oleoyl serine;
  • osteoporosis;
  • traumatic brain injury

Abstract

Over the last two decades a large number of N-long-chain acyl amino acids have been identified in the mammalian body. The pharmacological activities of only a few of them have been investigated and some have been found to be of considerable interest. Thus arachidonoyl serine is vasodilatory and neuroprotective, arachidonoyl glycine is antinociceptive, and oleoyl serine rescues bone loss. However, the pathophysiological/biochemical roles of these amides are mostly unknown. © 2014 BioFactors, 40(4):381–388, 2014