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Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

Authors

  • Javier Conde,

    1. NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Building C, Level-2, Santiago de Compostela, Spain
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  • Morena Scotece,

    1. NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Building C, Level-2, Santiago de Compostela, Spain
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  • Rodolfo Gómez,

    1. Fundación Jiménez Diaz, Division of Rheumatology, Madrid, Spain
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  • Verónica López,

    1. NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Building C, Level-2, Santiago de Compostela, Spain
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  • Juan Jesús Gómez-Reino,

    1. NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Building C, Level-2, Santiago de Compostela, Spain
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  • Francisca Lago,

    1. Molecular and Cellular Cardiology Laboratory, SERGAS, Santiago University Clinical Hospital, Santiago de Compostela, Spain
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  • Oreste Gualillo

    Corresponding author
    1. NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Building C, Level-2, Santiago de Compostela, Spain
    • NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Building C, Level-2, Santiago de Compostela, Spain
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    • Tel.: +34981950905; Fax: +


Abstract

Until the identification of leptin, the first adipokine discovered in 1994, adipose tissue was considered only as an energy storage tissue. However, it is now clear that adipose tissue is an endocrine/paracrine/autocrine organ, which plays a relevant role in physiopathology of several inflammatory diseases. Actually, it is mainly involved not only in the low-grade inflammatory status in obesity but also in other relevant inflammatory conditions and autoimmune disorders. In this review article, we discuss the main biological activities of leptin, adiponectin, lipocalin-2, resistin, and visfatin, as well as their contributions to certain inflammatory conditions.

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