Recent studies on the biofunctions and biotransformations of curcumin
Article first published online: 16 DEC 2008
Copyright © 2000 International Union of Biochemistry and Molecular Biology, Inc.
Volume 13, Issue 1-4, pages 153–158, 2000
How to Cite
Lin, J.-K., Pan, M.-H. and Lin-Shiau, S.-Y. (2000), Recent studies on the biofunctions and biotransformations of curcumin. BioFactors, 13: 153–158. doi: 10.1002/biof.5520130125
- Issue published online: 16 DEC 2008
- Article first published online: 16 DEC 2008
Curcumin is a major component of Curcuma species, which is commonly used as a yellow coloring and flavoring agent in foods. Curcumin has shown anti-carcinogenic activity in animals as indicated by its ability to block colon tumor initiation by azoxymethane and skin tumor promotion induced by phorbol ester TPA. Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase. Curcumin is also a potent inhibitor of protein kinase C, EGF-receptor tyrosine kinase and IκB kinase. Subsequently, curcumin inhibits the activation of NFκB and the expressions of c-jun, c-fos, c-myc and iNOS. It is proposed that curcumin may suppress tumor promotion through blocking signal transduction pathways in the target cells. Curcumin was first biotransformed to dihydrocurcumin and tetrahydrocurcumin and that these compounds subsequently were converted to monoglucuronide conjugates. These results suggest that curcumin-glucuronide, dihydro-curcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are major metabolites of curcumin in mice.