Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits
Article first published online: 19 DEC 2008
Copyright © 2006 International Union of Biochemistry and Molecular Biology, Inc.
Volume 26, Issue 1, pages 59–70, 2006
How to Cite
Mosimann, A. L. P., Wilhelm-Filho, D. and Da Silva, E. L. (2006), Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits. BioFactors, 26: 59–70. doi: 10.1002/biof.5520260106
- Issue published online: 19 DEC 2008
- Article first published online: 19 DEC 2008
- Manuscript Accepted: 5 NOV 2005
- Manuscript Revised: 26 OCT 2005
- Manuscript Received: 7 SEP 2005
- National Council for Scientific and Technological Development (CNPq -Brazil). Grant Number: 476959/01-6.
- Moinhos Unidos Brasil-Mate Co.,(Curitiba-PR, Brazil)
- Ilex paraguariensis;
- mate tea;
- antioxidant enzymes;
Ilex paraguariensis aqueous extract (mate) is an antioxidant-rich beverage widely consumed in South American countries. Here we questioned whether mate could reduce the progression of atherosclerosis in 1% cholesterol-fed rabbits. New Zealand White male rabbits (n = 32) were divided into four groups: control (C, n = 5), control-mate (CM, n = 5), hypercholesterolemic (HC, n = 11) and hypercholesterolemic-mate (HCM, n = 11). The daily water and mate extract consumption was approximately 400 ml. After 2 months of treatment, mate intake did not change the lipid profile or hepatic cholesterol content of control or hypercholesterolemic rabbits (p< 0.05). However, the atherosclerotic lesion area was considerably smaller in the hypercholesterolemic-mate group (HCM, 35.4% vs. HC, 60.1%; p<0.05). In addition, the aortic cholesterol content was around half that of the HC group (HCM, 36.8 vs. HC, 73.9 μ/mg of protein, p<0.05). In spite of this, the thiobarbituric acid-reactive substances (TBARS) in the atherosclerotic aorta, liver and serum, and the activity of the antioxidant enzymes in liver and aorta did not differ among groups (p>0.05). The results showed that Ilex paraguariensis extract can inhibit the progression of atherosclerosis in cholesterol-fed rabbits, although it did not decrease the serum cholesterol or aortic TBARS and antioxidant enzymes.