Thioredoxin-binding protein-2 (TBP-2): Its potential roles in the aging process
Article first published online: 19 DEC 2008
Copyright © 2006 International Union of Biochemistry and Molecular Biology, Inc.
Volume 27, Issue 1-4, pages 47–51, 2006
How to Cite
Yoshida, T., Kondo, N., Oka, S.-I., Ahsan, M. K., Hara, T., Masutani, H., Nakamura, H. and Ab, J. Y. (2006), Thioredoxin-binding protein-2 (TBP-2): Its potential roles in the aging process. BioFactors, 27: 47–51. doi: 10.1002/biof.5520270105
- Issue published online: 19 DEC 2008
- Article first published online: 19 DEC 2008
- Manuscript Accepted: 30 MAR 2006
- Manuscript Revised: 20 MAR 2006
- Manuscript Received: 5 JAN 2006
- Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan
- Bio-oriented Technology Research Advancement Institution (BRAIN)
- energy metabolism
Thioredoxin (TRX) binding protein-2 (TBP-2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP-2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP-2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP-2 was also reported to be a cellular senescence-associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP-2 genetically modified mice and found that TBP-2 is closely linked to lipid metabolism. Indeed, TBP-2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP-2 in the regulation of energy utilization connected to the aging process.