Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin
Article first published online: 16 DEC 2008
Copyright © 2004 International Union of Biochemistry and Molecular Biology, Inc.
Volume 21, Issue 1-4, pages 175–178, 2004
How to Cite
Murakami, T., Miyakoshi, M., Araho, D., Mizutani, K., Kambara, T., Ikeda, T., Chou, W.-H., Inukai, M., Takenaka, A. and Igarashi, K. (2004), Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin. BioFactors, 21: 175–178. doi: 10.1002/biof.552210136
- Issue published online: 16 DEC 2008
- Article first published online: 16 DEC 2008
- Ampelopsis grossedentata;
- alanine aminotransferase;
- aspartate aminotransferase
Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, α-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.