Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin

Authors

  • Toshiyuki Murakami,

    1. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan
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  • Masazumi Miyakoshi,

    Corresponding author
    1. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan
    • Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan. Tel.: +81 847 52 5501; Fax: +81 847 52 5901
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  • Daisuke Araho,

    1. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan
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  • Kenji Mizutani,

    1. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan
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  • Toshimitsu Kambara,

    1. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan
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  • Takao Ikeda,

    1. Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089–8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729–3102, Japan
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  • Wen-Hua Chou,

    1. South China Institute of Botany, Academia Sinica, Leyiji, Guangzhou 510650, P.R. China
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  • Mihoko Inukai,

    1. Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1–23 Wakaba-machi, Tsuruoka-shi, Yamagata 997–8555, Japan
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  • Asako Takenaka,

    1. Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1–23 Wakaba-machi, Tsuruoka-shi, Yamagata 997–8555, Japan
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  • Kiharu Igarashi

    1. Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1–23 Wakaba-machi, Tsuruoka-shi, Yamagata 997–8555, Japan
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Abstract

Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, α-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.

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