Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health

Authors

  • Filippos Ververidis Dr.,

    Corresponding author
    1. Laboratory of Plant Biochemistry and Biotechnology, Department of Plant Sciences, Technological Educational Institute of Crete, Heraklion, Crete, Greece
    • Laboratory of Plant Biochemistry and Biotechnology, Department of Plant Sciences, Technological Educational, Institute of Crete, P. O. Box 1939, GR-710 04 Heraklion, Crete, Greece, Fax: +30-2810-318204
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  • Emmanouil Trantas,

    1. Laboratory of Plant Biochemistry and Biotechnology, Department of Plant Sciences, Technological Educational Institute of Crete, Heraklion, Crete, Greece
    2. Department of Biology, University of Crete, Heraklion, Greece
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  • Carl Douglas,

    1. Department of Botany, University of British Columbia, Vancouver, Canada
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  • Guenter Vollmer,

    1. Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technische Universität Dresden, Dresden, Germany
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  • Georg Kretzschmar,

    1. Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technische Universität Dresden, Dresden, Germany
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  • Nickolas Panopoulos

    1. Department of Biology, University of Crete, Heraklion, Greece
    2. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece
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Abstract

Plant natural products derived from phenylalanine and the phenylpropanoid pathway are impressive in their chemical diversity and are the result of plant evolution, which has selected for the acquisition of large repertoires of pigments, structural and defensive compounds, all derived from a phenylpropanoid backbone via the plant-specific phenylpropanoid pathway. These compounds are important in plant growth, development and responses to environmental stresses and thus can have large impacts on agricultural productivity. While plant-based medicines containing phenylpropanoid-derived active components have long been used by humans, the benefits of specific flavonoids and other phenylpropanoid-derived compounds to human health and their potential for long-term health benefits have been only recognized more recently. In this part of the review, we discuss the diversity and biosynthetic origins of phenylpropanoids and particularly of the flavonoid and stilbenoid natural products. We then review data pertaining to the modes of action and biological properties of these compounds, referring on their effects on human health and physiology and their roles as plant defense and antimicrobial compounds. This review continues in Part II discussing the use of biotechnological tools targeting the rational reconstruction of multienzyme pathways in order to modify the production of such compounds in plants and model microbial systems for the benefit of agriculture and forestry.

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