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Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production

  1. Seung Bum Sohn1,2,
  2. Alexandra B. Graf3,4,
  3. Tae Yong Kim1,2,
  4. Brigitte Gasser3,
  5. Michael Maurer4,
  6. Pau Ferrer5,
  7. Diethard Mattanovich Professor3,
  8. Sang Yup Lee Professor1,2,6,*

Article first published online: 25 MAY 2010

DOI: 10.1002/biot.201000078

Issue

Biotechnology Journal

Biotechnology Journal

Special Issue: Systems Biology for Biotech Applications

Volume 5, Issue 7, pages 705–715, July 2010

Additional Information

How to Cite

Sohn, S. B., Graf, A. B., Kim, T. Y., Gasser, B., Maurer, M., Ferrer, P., Mattanovich, D. and Lee, S. Y. (2010), Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production. Biotechnology Journal, 5: 705–715. doi: 10.1002/biot.201000078

Author Information

  1. 1

    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon, Republic of Korea

  2. 2

    Bioinformatics Research Center, KAIST, Daejeon, Republic of Korea

  3. 3

    Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria

  4. 4

    School of Bioengineering, University of Applied Sciences FH-Campus Wien, Vienna, Austria

  5. 5

    Department d'Enginyeria Química, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Bellaterra, Spain

  6. 6

    Department of Bio and Brain Engineering and Bioinformatics Research Center, KAIST, Daejeon, Republic of Korea

*Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Republic of Korea, Fax: +82423503910

Publication History

  1. Issue published online: 14 JUL 2010
  2. Article first published online: 25 MAY 2010
  3. Manuscript Accepted: 18 MAY 2010
  4. Manuscript Revised: 13 MAY 2010
  5. Manuscript Received: 3 MAY 2010

Funded by

  • Korean Systems Biology Research Project of the Ministry of Education, Science and Technology through the National Research Foundation of Korea
  • Austrian Science Fund
  • Austrian Research Promotion Agency

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