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Direct assembling methodologies for high-throughput bioscreening

Authors

  • Jorge I. Rodríguez-Dévora,

    1. Biomedical Engineering Program and Department of Mechanical Engineering, University of Texas at El Paso, El Paso, TX, USA
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  • Zhi-dong Shi,

    1. Department of Neurosurgery, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China
    2. Medprin Regenerative Medical Technologies Co., Ltd., Guangzhou, Guangdong Province, China
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  • Dr. Tao Xu

    Corresponding author
    1. Biomedical Engineering Program and Department of Mechanical Engineering, University of Texas at El Paso, El Paso, TX, USA
    2. Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA
    • Department of Mechanical Engineering, Engineering Bldg. A226, University of Texas at El Paso, 500 W University Avenue, El Paso, Texas 79968, USA
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Abstract

Over the last few decades, high-throughput (HT) bioscreening, a technique that allows rapid screening of biochemical compound libraries against biological targets, has been widely used in drug discovery, stem cell research, development of new biomaterials, and genomics research. To achieve these ambitions, scaffold-free (or direct) assembly of biological entities of interest has become critical. Appropriate assembling methodologies are required to build an efficient HT bioscreening platform. The development of contact and non-contact assembling systems as a practical solution has been driven by a variety of essential attributes of the bioscreening system, such as miniaturization, high throughput, and high precision. The present article reviews recent progress on these assembling technologies utilized for the construction of HT bioscreening platforms.

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