Microfabricated particulate drug-delivery systems

Authors

  • Jing Pan,

    1. Department of Pharmacy, National University of Singapore, Singapore
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  • Sui Yung Chan,

    1. Department of Pharmacy, National University of Singapore, Singapore
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  • Prof. Won Gu Lee,

    Corresponding author
    1. Department of Mechanical Engineering, College of Engineering, Kyung Hee University, Gyeonggi, Republic of Korea
    • Department of Mechanical Engineering, College of Engineering, Kyung Hee University, 1 Seochon, Giheung, Yongin, Gyeonggi 446-701, Republic of Korea
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    • These authors contributed equally to this work.

  • Dr. Lifeng Kang

    Corresponding author
    1. Department of Pharmacy, National University of Singapore, Singapore
    • Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543
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    • These authors contributed equally to this work.


Abstract

Micro- and nanoparticulate drug-delivery systems (DDSs) play a significant role in formulation sciences. Most particulate DDSs are scaffold-free, although some particles are encapsulated inside other biomaterials for controlled release. Despite rapid progress in recent years, challenges still remain in controlling the homogenicity of micro-/nanoparticles, especially for two crucial factors in particulate DDSs: the size and shape of the particles. Recent approaches make use of microfabrication techniques to generate micro-/nanoparticles with highly controllable architectures free of scaffolds. This review presents an overview of a burgeoning field of DDSs, which can potentially overcome some drawbacks of conventional techniques for particle fabrication and offer better control of particulate DDSs.

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