Microfluidic tools for developmental studies of small model organisms –nematodes, fruit flies, and zebrafish

Authors

  • Hyundoo Hwang,

    1. School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
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  • Prof. Hang Lu

    Corresponding author
    1. School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    • School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr. NW, Atlanta, GA, USA
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Abstract

Studying the genetics of development with small model organisms such as the zebrafish (Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil-dwelling nematode (Caenorhabditis elegans), provide unique opportunities for understanding related processes and diseases in humans. These model organisms also have potential for use in drug discovery and toxicity-screening applications. There have been sweeping developments in microfabrication and microfluidic technologies for manipulating and imaging small objects, including small model organisms, which allow high-throughput quantitative biological studies. Here, we review recent progress in microfluidic tools able to manipulate small organisms and project future directions and applications of these techniques and technologies.

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