How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?



This report highlights the potential of measurement, monitoring, modeling and control (M3C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M3C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M3C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M3C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.