This report highlights the potential of measurement, monitoring, modeling and control (M3C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M3C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M3C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M3C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.