Numerous studies have shown that cell cultures in tissue culture plates and flasks do not reproduce the in vivo growth behavior of cells and have a poor correlation with animal as well human clinical data. Additive three-dimensional (3D) tissue-printing technology developed by regenHU Ltd, Villaz-St-Pierre, Switzerland, provides a promising new tool for tissue engineers, capable of creating organotypic tissues with true-to-life morphology that better mirrors the environment experienced by cells in vivo. Several studies show that tissues created using regenHU's BioFactory® and 3DDiscovery® bio-printing platforms can model natural cell behavior, intercellular interactions and differentiation processes.
The key advantage of this new tissue manufacturing technology resides in the fact that regenHU's bio-printer builds up tissue in a layer-upon-layer process. Thus, cells, signal molecules, and biomaterials, such as biopolymers, synthetic or natural hydrogels or calcium phosphates, form a highly dynamic network of proteins and signal transduction pathways. The printed, 3D cell-cell and cell-extracellular matrix closely resembles natural tissue. Its well-defined structure enables the control and study of biological and mechanical cell/molecule interaction processes.
For its 3D tissue-printing platform, regenHU has created BioInk®, a hydrogel that promotes cell growth for different cells by providing cell adhesion sites and mimicking the natural extracellular matrix. Bioink® is available as a ready-to-use solution to print 3D tissues. With BioInk®, critical parameters such as matrix stiffness, cell adhesion and the ability to create pre-defined 3D shapes with tissue-printing devices can be tailored. The BioInk® cartridges are specifically designed for BioFactory® and 3DDiscovery® tissue printers, enabling researchers to create composite tissue models with full spatial control of the allocation and distribution of bioactive components.
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