Biomimetic soluble collagen purified from bones (pages 1386–1394)
Ana Marina Ferreira, Piergiorgio Gentile, Susanna Sartori, Cristina Pagliano, Chiara Cabrele, Valeria Chiono and Prof. Gianluca Ciardelli
Article first published online: 15 AUG 2012 | DOI: 10.1002/biot.201200184
Absence of proteoglycans in collagen fibres mimic pathological conditions associated with aging-related diseases: the current study demonstrates that the absence of proteoglycans in isolated type I collagen affects its thermal properties, the extraction into its native structure, and its capability to hydrate and self-assemble into fibres. The fine control and tuning of all these features linked to the absence of non-collagenous proteins such as proteoglycans offer the possibility to design new strategies and biomaterials with advanced biomimetic properties aimed at regenerating bone tissue.