How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? (pages 1522–1529)
Manuel J. T. Carrondo, Paula M. Alves, Nuno Carinhas, Jarka Glassey, Friedemann Hesse, Otto-Wilhelm Merten, Martina Micheletti, Thomas Noll, Rui Oliveira, Udo Reichl, Arne Staby, Ana P. Teixeira, Henry Weichert and Prof. Carl-Fredrik Mandenius
Version of Record online: 5 SEP 2012 | DOI: 10.1002/biot.201200226
The potential of measurement, monitoring, modeling and control (M3C) methodologies in animal and human cell culture technology is highlighted by an expert panel of biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M3C are discussed from a cell culture perspective for industrial process development and production needs. The report provides a set of recommendations for targeting M3C research towards the industrial interests.