Biotechnology Journal

Cover image for Vol. 7 Issue 6

Special Issue: Stem cells and materials

June 2012

Volume 7, Issue 6

Pages 693–823, A1–A8

  1. Cover Picture

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    3. Editorial Board
    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
    8. Forum
    9. Reviews
    10. Mini-Review
    11. Reviews
    12. Meetings
    13. Correction
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      Stem cells and materials

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201290029

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      Special issue: Stem cells and materials. This BTJ Special issue features the highlights of a conference jointly organized by the Collaborative Research Center SFB 873 of the University of Heidelberg, Germany, and the Institute for Institute for Integrated Cell-Material Sciences (WPI-iCeMS) of Kyoto University, Japan, which was held in July 2011. The cover image depicts the Heidelberg Castle (right) and the pagoda at Toji in Kyoto (left), joined by an EM image of the mesoscopic structures in a cell membrane, taken by iCeMS Prof. John Heuser. Design created by David Hajime Kornhauser (Kyoto University).

  2. Editorial Board

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    3. Editorial Board
    4. Editorial
    5. In this issue
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    10. Mini-Review
    11. Reviews
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    13. Correction
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      Editorial Board: Biotechnology Journal 6/2012 (page 693)

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201290034

  3. Editorial

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    4. Editorial
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      Editorial: “Crossing Boundaries: Stem Cells, Materials, and Mesoscopic Sciences” (pages 694–695)

      Prof. Anthony Ho and Prof. Norio Nakatsuji

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201200156

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      “Crossing Boundaries: Stem Cells, Materials, and Mesoscopic Sciences”. This Special Issue, edited by Prof. Anthony Ho and Prof. Norio Nakatsuji, comprises review articles on the interdisciplinary study of stem cells and material science and is a celebration of the friendship and collaboration between Heidelberg University and Kyoto University in Germany and Japan, respectively.

  4. In this issue

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
    8. Forum
    9. Reviews
    10. Mini-Review
    11. Reviews
    12. Meetings
    13. Correction
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      In this issue (page 696)

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201290030

  5. Contents

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
    8. Forum
    9. Reviews
    10. Mini-Review
    11. Reviews
    12. Meetings
    13. Correction
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      Contents: Biotechnology Journal 6/2012 (pages 697–698)

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201290031

  6. BiotecVisions

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    4. Editorial
    5. In this issue
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    7. BiotecVisions
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    9. Reviews
    10. Mini-Review
    11. Reviews
    12. Meetings
    13. Correction
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  7. Forum

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    13. Correction
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      Heidelberg-Kyoto partnership bridges life and materials sciences, strengthens bilateral ties (pages 699–700)

      Yutaka Iijima, David H. Kornhauser and Norio Nakatsuji

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201200166

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      Coinciding with the 150th anniversary of German-Japanese friendship, Kyoto University and Heidelberg University, two universities replete with history and tradition strengthened their close ties at a joint meeting in Heidelberg, Germany, forming the core of a broad collaborative effort between the two countries. This forum article provides a background and overview of the collaborations.

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      Biotechnology essay competition: Biotechnology Journal contributes to World Environment Day (page 701)

      Judy Peng

      Article first published online: 3 MAY 2012 | DOI: 10.1002/biot.201200171

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      In celebration of this year's World Environment Day, June 5, Biotechnology Journal is hosting an essay competition for high school students with the topic “biotechnology and the green economy”. Submission is open to all – see article for further details.

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      Biomaterials in medical devices: An Interview with Jörg Vienken of Fresenius Medical Care, Germany (pages 702–703)

      Judy Peng

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201200147

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      Biomaterial and biopolymer research have significant impact on the development as well as application of biotechnology. Biotechnology Journal recently attended the “Nanomaterials for Biomedical Technologies 2012” conference. We were privileged to have the opportunity to ask Prof. Dr. Jörg Vienken, VP of BioSciences at Fresenius Medical Care, a few questions relating to medical devices, the importance of publishing for industry, and also his advice for young scientists/engineers looking for a career in industry.

  8. Reviews

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    10. Mini-Review
    11. Reviews
    12. Meetings
    13. Correction
    1. Stem cells: A view from the roots (pages 704–722)

      Dr. Ildiko M. L. Somorjai, Jan U. Lohmann, Thomas W. Holstein and Dr. Zhong Zhao

      Article first published online: 14 MAY 2012 | DOI: 10.1002/biot.201100349

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      In this review, the authors discuss key aspects of stem cell regulation in model plants and animal systems, including elements of the stem cell niche, shared components of the epigenetic machinery and small RNA processing. Data from basal groups are beginning to provide new insight into the evolution of stem cell regulation in eukaryotes. An understanding of such basic mechanisms promises to be an important source for new technologies in medicine and agriculture (images courtesy of Wikimedia Commons, except Hydra, by TW Holstein and M Mikosch).

    2. Shaping the niche: Lessons from the Drosophila testis and other model systems (pages 723–736)

      Fani Papagiannouli and Dr. Ingrid Lohmann

      Article first published online: 5 APR 2012 | DOI: 10.1002/biot.201100352

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      Stem cell regulation relies on intrinsic signals and inputs emanating from the neighbouring niche. Transcription factors, such as the Hox genes, play a critical role as they are often the input or output of these signaling pathways, whereas physical contacts between the stem cells and other niche cell populations allow the exchange of diffusible signals. This review discusses aspects of niche establishment and integrity in the Drosophila testis not yet fully understood and compare it to the current knowledge in other model systems such as vertebrates and plants.

    3. Stochastic processes in the development of pluripotency in vivo (pages 737–744)

      Sebastian Wennekamp and Dr. Takashi Hiiragi

      Article first published online: 27 APR 2012 | DOI: 10.1002/biot.201100357

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      Recently, an unexpected heterogeneity in transcription factor expression by stem cell populations during early mouse development has raised the idea that stochastic processes may be crucial in the establishment and maintenance of pluripotency. As a result of advances in molecular biology and imaging, this intriguing possibility can now be explored further and provide a new perspective on the nature of pluripotency. In this review, the authors discuss three models for establishing cellular differentiation in the mouse embryo, and the heterogeneity in transcription factor expression during early development.

    4. Reaction kinetics in the plasma membrane (pages 745–752)

      Dr. Ziya Kalay

      Article first published online: 29 FEB 2012 | DOI: 10.1002/biot.201100362

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      Heterogeneous and dynamic nature of the plasma membrane can affect reaction kinetics and membrane function: recent experimental results indicate that the plasma membrane of cells, where many critical signaling events start, is a highly heterogeneous and dynamic medium containing specialized domains such as actin cytoskeleton-induced domains, lipid rafts, and more. In this review, the author provides insight to how some of these specialized domains can help regulate molecular interactions, and in turn, cellular processes.

    5. Lipid rafts generate digital-like signal transduction in cell plasma membranes (pages 753–761)

      Dr. Kenichi G. N. Suzuki

      Article first published online: 5 APR 2012 | DOI: 10.1002/biot.201100360

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      Lipid rafts are thought to be meso-scale platforms where signaling molecules assemble and function. Recent advanced imaging techniques have revealed that GPI-anchored receptors such as CD59 form clusters that transiently recruit signaling molecules with the aid of protein-protein, protein-lipid, and/or lipid-lipid interactions. This review article provides a concise overview of how digital-like signal transduction is generated by transient interactions between raft molecules.

  9. Mini-Review

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    6. Contents
    7. BiotecVisions
    8. Forum
    9. Reviews
    10. Mini-Review
    11. Reviews
    12. Meetings
    13. Correction
    1. Phospholipid nanodisc engineering for drug delivery systems (pages 762–767)

      Dr. Tatsuya Murakami

      Article first published online: 14 MAY 2012 | DOI: 10.1002/biot.201100508

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      Mesoscale nanoparticles are attractive tools for drug delivery. To achieve biocompatibility, these particles are often coated with PEG, which can have problems with antigenicity and cellular update. HDL-like phospholipid nanodiscs generated in vitro are evolving as new and promising biocompatible drug carriers as they are very close to natural HDL and can be adjusted as needed through a wide variety of genetic and chemical modifications. This review provides a succinct overview of the use of synthetic HDL-like phospholipid nanodiscs as biocompatible drug carriers.

  10. Reviews

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    12. Meetings
    13. Correction
    1. Systematic approaches to dissect biological processes in stem cells by image-based screening (pages 768–778)

      Gerrit Erdmann, Christian Volz and Prof. Michael Boutros

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201200117

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      Imaging has become an increasingly important tool in high-throughput screening, enabling researchers to monitor changes in complex phenotypes such as cell morphology and cell differentiation. In this review, the authors discuss the use of image-based screening approaches to further understand pluripotent stem cells.

    2. Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance (pages 779–788)

      Van Thanh Hoang, Abraham Zepeda-Moreno and Prof. Anthony D. Ho

      Article first published online: 16 MAY 2012 | DOI: 10.1002/biot.201100350

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      Similar to normal hematopoietic stem cells (HSC), leukemic stem cells (LSC) that reside within the niches divide very slowly and hence, are resistant against conventional anti-proliferating drugs. Upon chemotherapy, although the bulk of leukemic cells are killed, some LSC survive and are able to repopulate resulting in relapse. Disrupting adhesion of LSC to the niche or targeting their protective microenvironment may represent alternative pathways to render LSC vulnerable to chemotherapy or immune modulation such as allogeneic HSC transplantation.

    3. Methods for iPS cell generation for basic research and clinical applications (pages 789–797)

      Yuji Mochiduki and Dr. Keisuke Okita

      Article first published online: 29 FEB 2012 | DOI: 10.1002/biot.201100356

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      Currently, induced pluripotent stem (iPS) cells can be established by various methods. The factors affecting iPS reprogramming can be categorized into four groups: (i) the combination of reprogramming factors, (ii) the induction method of reprogramming factors, (iii) the culture conditions and the type of original somatic cells, and (iv) the origin of the cells. This review discusses recent advancements in the field.

    4. Programmable genetic switches to control transcriptional machinery of pluripotency (pages 798–809)

      Ganesh N. Pandian and Prof. Hiroshi Sugiyama

      Article first published online: 16 MAY 2012 | DOI: 10.1002/biot.201100361

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      The ability to control the pluoripotent state of cells has great implications for therapeutic applications. Programmable genetic switches offers versatile medical applications as transcriptional activation could control the specification of cellular phenotype. In this review, the authors propose that the combination of genetic “ON” and “OFF” switches consisting of small DNA-binding hairpin pyrrole-imidazole polyamides could potentially trigger and control transcriptional machinery of pluripotency via site-specific histone modifications and DNA alkylation.

    5. Mediators of induced pluripotency and their role in cancer cells – current scientific knowledge and future perspectives (pages 810–821)

      Mathias Bernhardt, Marta Galach, Daniel Novak and Dr. Jochen Utikal

      Article first published online: 16 MAY 2012 | DOI: 10.1002/biot.201100347

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      Reprogramming of somatic cells and tumorigenesis is driven by similar mechanisms: The process of reprogramming somatic cells into induced pluripotent stem cells (iPSCs) is mediated by tumor suppressor genes and driven by transcription factors that are involved in tumorigenesis. The generation of induced pluripotent cancer cells (iPCCs) from cancer cells can provide a tool to simulate tumor development and to identify novel therapeutic targets for cancer treatment. This review gives an overview of the common features of pluripotent stem cells and cancer cells.

  11. Meetings

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      Meetings and Conferences: Biotechnology Journal 6/2012 (pages 822–823)

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201290032

  12. Correction

    1. Top of page
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    3. Editorial Board
    4. Editorial
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    6. Contents
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    13. Correction
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      Correction to: Screening of cell-penetrating peptides using mRNA display (page 823)

      Jae-Hun Lee, Hyun Seok Song, Sun-Gu Lee, Tai Hyun Park and Byung-Gee Kim

      Article first published online: 1 JUN 2012 | DOI: 10.1002/biot.201290033

      This article corrects:

      Screening of cell-penetrating peptides using mRNA display

      Vol. 7, Issue 3, 387–396, Article first published online: 16 DEC 2011

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