Biotechnology Journal

Cover image for Vol. 8 Issue 8

Special Issue: Systems & Synthetic Industrial Biotechnology

August 2013

Volume 8, Issue 8

Pages 869–959, A1–A8

  1. Cover Picture

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    3. Editorial Board
    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
    8. Forum
    9. Review
    10. Research Articles
    11. Technical Report
    12. Reviews
    13. Research Article
    14. Correction
    15. Meetings
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      Systems & Synthetic Industrial Biotechnology

      Article first published online: 2 AUG 2013 | DOI: 10.1002/biot.201390037

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      This Special Issue on “Systems and Synthetic Approaches to Industrial Biotechnology” compiles the outcomes of the minisymposiumat the 31st General Assembly of the International Union of Biological Sciences (IUBS). Implementation of systems biology and synthetic biology approaches in engineering industrial microbes and processes provides a promising and straight-forward approach to linking basic and application-inspired research. The cover represents the various concepts involved in systems and synthetic biotechnology. Image: © kytalpa – Fotolia.com.

  2. Editorial Board

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    7. BiotecVisions
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      Editorial Board: Biotechnology Journal 8/2013 (page 869)

      Article first published online: 2 AUG 2013 | DOI: 10.1002/biot.201390042

  3. Editorial

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      Editorial: Systems and synthetic approaches to industrial biotechnology (pages 870–871)

      Prof. Yin Li and Prof. Johannes H. de Winde

      Article first published online: 2 AUG 2013 | DOI: 10.1002/biot.201300331

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      The advances in genomics, systems biology and most recently, synthetic biology, provide unprecedented opportunities for industrial biotechnologists to develop novel biocatalysts and other bio-tools that may enable efficient and cost-effective biological conversion processes.

  4. In this issue

    1. Top of page
    2. Cover Picture
    3. Editorial Board
    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
    8. Forum
    9. Review
    10. Research Articles
    11. Technical Report
    12. Reviews
    13. Research Article
    14. Correction
    15. Meetings
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  5. Contents

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    3. Editorial Board
    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
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    9. Review
    10. Research Articles
    11. Technical Report
    12. Reviews
    13. Research Article
    14. Correction
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      Contents: Biotechnology Journal 8/2013 (pages 873–874)

      Article first published online: 2 AUG 2013 | DOI: 10.1002/biot.201390039

  6. BiotecVisions

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    4. Editorial
    5. In this issue
    6. Contents
    7. BiotecVisions
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    10. Research Articles
    11. Technical Report
    12. Reviews
    13. Research Article
    14. Correction
    15. Meetings
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  7. Forum

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    7. BiotecVisions
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      Bridging current issues in science and society (pages 875–877)

      Robin L. Pierce

      Article first published online: 15 JUL 2013 | DOI: 10.1002/biot.201200264

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      This bioethics article by Robin Pierce, examines the current challenges in bridging science and society. Dr. Pierce discusses the “bi-directionality challenge” and how a meaningful dialogue between scientists and society can be established for socially responsible innovations. (Image: © XtravaganT – Fotolia.com)

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      Book review: Extreme Tissue Engineering – Concepts and Strategies for Tissue Fabrication (pages 878–879)

      Prof. Sujata K. Bhatia

      Article first published online: 7 JUN 2013 | DOI: 10.1002/biot.201200402

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      In this new book, Extreme Tissue Engineering – Concepts and strategies for Tissue Fabrication, Robert A. Brown advocates an “extreme” approach to tissue engineering. Read this book review by Sujata Bhatia to gain an insight to this thought-provoking new title.

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      Book review: Production of Plasma Proteins for Therapeutic Use (pages 880–881)

      Kjell Eriksson

      Article first published online: 7 JUN 2013 | DOI: 10.1002/biot.201300141

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      Production of Plasma Proteins for Therapeutic Use edited by Joseph Bertolini, Neil Goss and John Curling provides comprehensive data for the plasma area. This comprehensive book covers the topics of the biology of plasma proteins and their production, from blood plasma collection to finished products, and also gives a description of these products' clinical use. Read this book review by Dr. Kjell Eriksson to find out more about this book.

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      Meeting report: Trends in Bioanalytical Imaging (pages 882–883)

      Judy Peng

      Article first published online: 11 JUL 2013 | DOI: 10.1002/biot.201300254

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      “Trends in Bioanalytical Imaging” – a DECHEMA event, was organized by leaders in bioanalytical imaging in Germany and took place in Frankfurt am Main on May 27–28, 2013. This meeting report covers the Raman spectroscopy section of the meeting. Image: MSI of barley grain, (©) Karin Gorzolka.

  8. Review

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    10. Research Articles
    11. Technical Report
    12. Reviews
    13. Research Article
    14. Correction
    15. Meetings
    1. Physiological and molecular aspects of degradation of plant polysaccharides by fungi: What have we learned from Aspergillus? (pages 884–894)

      Helena Culleton, Vincent McKie and Dr. Ronald P. de Vries

      Article first published online: 15 MAY 2013 | DOI: 10.1002/biot.201200382

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      Aspergillus have become the most widely studied filamentous fungi due to its potential in biomass degradation. This review presents an outline of the complex structure of plant biomass, the large range of diverse enzymes produced by Aspergillus specifically tailored to its degradation and the regulatory systems involved in the expression of the corresponding genes.

  9. Research Articles

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    1. Genotypic adaptations associated with prolonged persistence of Lactobacillus plantarum in the murine digestive tract (pages 895–904)

      Hermien van Bokhorst-van de Veen, Maaike J. Smelt, Michiel Wels, Sacha A. F. T. van Hijum, Paul de Vos, Prof. Michiel Kleerebezem and Peter A. Bron

      Article first published online: 13 MAY 2013 | DOI: 10.1002/biot.201200259

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      Probiotic bacteria harbor adaptation factors that enable them to persist in the gastrointestinal tract of the consumer. The work presented here demonstrates the feasibility of experimental evolution for the enhancement of the gastrointestinal residence time of probiotic strains, while full-genome re-sequencing of the adapted isolates provides clues towards the bacterial functions involved in the altered phenotype.

    2. Disruption of the L-arabitol dehydrogenase encoding gene in Aspergillus tubingensis results in increased xylanase production (pages 905–911)

      Igor Nikolaev, Sara Farmer Hansen, Susan Madrid and Dr. Ronald P. de Vries

      Article first published online: 26 JUN 2013 | DOI: 10.1002/biot.201200256

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      Improving the production of fungal xylanases is of major importance to many industrial sectors, such as food & feed, paper & pulp and biofuel. In this study, the authors observe an increase in xylanase production in an industrial mutant strain Aspergillus tubingensis. They show that the increased xylanase production is caused by disruption of the ladA gene which is part of L-arabinose catabolism, and its gene product L-arabitol dehydrogenase converts L-arabitol to L-xylulose. This study demonstrates that metabolic engineering could be an alternative approach for increasing xylanase production, as opposed to increasing the expression of the xylanase encoding genes.

  10. Technical Report

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    1. Mid-infrared spectroscopy-based antibody aggregate quantification in cell culture fluids (pages 912–917)

      Florian Capito, Romas Skudas, Harald Kolmar and Christian Hunzinger

      Article first published online: 21 JUN 2013 | DOI: 10.1002/biot.201300164

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      Therapeutic antibody processing and purification involves several steps, potentially inducing antibody aggregation. This study reports the use of infrared spectroscopy to quantify the amount of antibody aggregates in cell culture fluid and post protein A eluate. Results showed the principal suitability of this technique with prediction ability down to 1% aggregates compared to overall antibody amount and with coefficients of variation for most samples below 20%. Compared to more traditional techniques, this is a faster and more economic way for monitoring antibody aggregation.

  11. Reviews

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    1. Bioportides: Bioactive cell-penetrating peptides that modulate cellular dynamics (pages 918–930)

      Monika Lukanowska, John Howl and Dr. Sarah Jones

      Article first published online: 11 JUL 2013 | DOI: 10.1002/biot.201200335

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      Bioportides, i.e. cell-penetrant peptide modulators of signal transduction, translocate biological membranes to directly target intracellular protein-protein interactions. This review aims to propound bioportides' utility as both research tools and potential therapeutics for a wide range of pathologies.

    2. Polymer-based stimuli-responsive nanosystems for biomedical applications (pages 931–945)

      Madhura Joglekar and Prof. Brian G. Trewyn

      Article first published online: 11 JUL 2013 | DOI: 10.1002/biot.201300073

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      Stimuli-responsive or “intelligent” polymers have been widely used for the design of polymeric nanosystems such as polymeric micelles, polymersomes, nanohydrogels and hybrid nanosystems consisting of inorganic nanoparticles. Application of an internal or external trigger such as pH, temperature, redox, magnetic, light or ultrasound causes these nanosystems to undergo structural changes which releases the payload at the target site. The widespread interest among the scientific community has led to the exploration of various applications such as site-specific drug delivery, bioimaging, tissue regeneration and bioseparation, which are discussed in this review.

  12. Research Article

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    1. Reduction of product-related species during the fermentation and purification of a recombinant IL-1 receptor antagonist at the laboratory and pilot scale (pages 946–956)

      Dr. Emily B. Schirmer, Kathryn Golden, Jin Xu, Jesse Milling, Alec Murillo, Patricia Lowden, SriHariRaju Mulagapati, Jinzhao Hou, Joseph T. Kovalchin, Allyson Masci, Kathryn Collins and Gregory Zarbis-Papastoitsis

      Article first published online: 2 AUG 2013 | DOI: 10.1002/biot.201300189

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      Tracking product quality through process development for both upstream and downstream operations is a useful tool to process engineers in biologics development and scale-up. In this study, authors take a parallel approach to reduce undesired product-related species by modulating host cell enzymatic activity during fermentation and by exploiting small biochemical differences during purification. By designing robust upstream and downstream processes based on maintaining high levels of product quality, the authors demonstrate the ability of the process to produce quality drug substance at laboratory and commercial scales.

  13. Correction

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      Corrigendum to: Endotoxin removal and prevention for pre-clinical biologics production (page 957)

      Anne Serdakowski London, Brendan Kerins, William R. Tschantz, Jochen Eisfeld and Kasey Mackay

      Article first published online: 2 AUG 2013 | DOI: 10.1002/biot.201390040

      This article corrects:

      Endotoxin removal and prevention for pre-clinical biologics production

      Vol. 7, Issue 12, 1509–1516, Article first published online: 9 NOV 2012

  14. Meetings

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