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Artificial diiron proteins: From structure to function†

  1. Jennifer R. Calhoun1,2,
  2. Flavia Nastri3,
  3. Ornella Maglio3,‡,
  4. Vincenzo Pavone3,
  5. Angela Lombardi3,*,
  6. William F. DeGrado1,2,*

Article first published online: 7 FEB 2005

DOI: 10.1002/bip.20230

Issue

Peptide Science

Peptide Science

Special Issue: Goodman Special Issue

Volume 80, Issue 2-3, pages 264–278, 2005

Additional Information

How to Cite

Calhoun, J. R., Nastri, F., Maglio, O., Pavone, V., Lombardi, A. and DeGrado, W. F. (2005), Artificial diiron proteins: From structure to function. Biopolymers, 80: 264–278. doi: 10.1002/bip.20230

Author Information

  1. 1

    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 USA

  2. 2

    Department of Chemistry, University of Pennsylvania, 231 South 34 Street, Philadelphia, PA 19104 USA

  3. 3

    Department of Chemistry, University of Naples “Federico II” Via Cinthia, I-80126 Naples, Italy

  1. ‡

    Istituto di Biostrutture e Bioimmagini—CNR, Via Mezzocannone 6, 80134 Napoli, Italy

*Department of Chemistry, University of Naples “Federico II” Via Cinthia, I-80126 Naples, Italy

  1. †

    This paper is dedicated to the memory of Murray Goodman, an outstanding scientist and a great pioneer in peptide chemistry. We will always remember not only his contributions to science, but also his humanity and enthusiasm for life.

Publication History

  1. Issue published online: 19 APR 2005
  2. Article first published online: 7 FEB 2005
  3. Manuscript Accepted: 15 DEC 2004
  4. Manuscript Received: 6 DEC 2004

Funded by

  • NIH. Grant Number: GM54616
  • Italian Ministry of the University and Scientific Research. Grant Number: PRIN 20003037580

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Keywords:

  • de novo protein design;
  • computational protein design;
  • metalloprotein;
  • diiron protein;
  • structure

Abstract

De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2005

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