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Membrane interactions of designed cationic antimicrobial peptides: The two thresholds^†

Evgenia Glukhov^1,2,
Lori L. Burrows³,
Charles M. Deber^1,2,*

Article first published online: 8 JAN 2008

DOI: 10.1002/bip.20917

Issue

Biopolymers

Special Issue: This issue is dedicated to the memory of Elkan R. Blout, a founding editor of Biopolymers

Volume 89, Issue 5, pages 360–371, May 2008

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How to Cite

Glukhov, E., Burrows, L. L. and Deber, C. M. (2008), Membrane interactions of designed cationic antimicrobial peptides: The two thresholds. Biopolymers, 89: 360–371. doi: 10.1002/bip.20917

Author Information

¹
Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8
²
Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
³
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

Email: Charles M. Deber (deber@sickkids.ca)

^*Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8

^†
This paper is dedicated to the memory of Professor Elkan Blout. C.M.D. had the privilege of being a post-doctoral associate in Elkan's lab at Harvard Medical School. It was the gift of Elkan that under his mentorship, one not only learned science, but also learned how to be a scientist. Elkan had the knack to recognize the important problems of the day, and see the big picture solutions. And equally important, he set the tone that encouraged each of us to work independently while at the same time enjoying the interchange of the group's ideas. I will always value Elkan's support and development of the young me, and the wonderful interactions I had with him, his wife Gail, and with labmates, over many subsequent years.

Publication History

Issue published online: 28 FEB 2008
Article first published online: 8 JAN 2008
Manuscript Accepted: 17 DEC 2007
Manuscript Received: 12 NOV 2007

Funded by

Canadian Institutes of Health Research (CIHR)
Natural Sciences and Engineering Research Council of Canada (NSERC)
Elsie Winifred Crann Memorial fund

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REFERENCES

1
Gallo, R. L.;Huttner, K. M. J Invest Dermatol 1998, 111, 739–743.
2
Epand, R. M.;Vogel, H. J. Biochim Biophys Acta 1999, 1462, 11–28.
3
Zasloff, M. Nature 2002, 415, 389–395.
4
Bulet, P.;Stocklin, R.;Menin, L. Immunol Rev 2004, 198, 169–184.
Direct Link:
5
Papo, N.;Shai, Y. Biochemistry 2004, 43, 6393–6403.
6
Mookherjee, N.;Hancock, R. E. Cell Mol Life Sci 2007, 64, 922–933.
7
Hancock, R. E. Lancet 1997, 349, 418–422.
8
Oren, Z.;Shai, Y. Biopolymers 1998, 47, 451–463.
Direct Link:
9
Bessalle, R.;Kapitkovsky, A.;Gorea, A.;Shalit, I.;Fridkin, M. FEBS Lett 1990, 274, 151–155.
10
Lee, W. J.;Brey, P. T. Anal Biochem 1994, 217, 231–235.
11
Shai, Y. Biopolymers 2002, 66, 236–248.
Direct Link:
12
Op den Kamp, J. A. Annu Rev Biochem 1979, 48, 47–71.
13
Barbin, A.;Peypoux, F.;Michel, G. Biochim Biophys Acta 1976, 431, 416–425.
14
Toke, O. Biopolymers 2005, 80, 717–735.
Direct Link:
15
Ludtke, S. J.;He, K.;Heller, W. T.;Harroun, T. A.;Yang. L.;Huang, H. W. Biochemistry 1996, 35, 13723–13728.
16
Stark, M.;Liu, L. P.;Deber, C. M. Antimicrob Agents Chemother 2002, 46, 3585–3590.
17
Liu, L. P.;Deber, C. M. Biochemistry 1997, 36, 5476–5482.
18
Liu, L. P.;Deber, C. M. J Biol Chem 1998, 273, 23645–23648.
19
Burrows, L. L.;Stark, M.;Chan, C.;Glukhov, E.;Sinnadurai, S.;Deber, C. M. J Antimicrob Chemother 2006, 57, 899–907.
20
Glukhov, E.;Stark, M.;Burrows, L. L.;Deber, C. M. J Biol Chem 2005, 280, 33960–33967.
21
Wieprecht, T.;Dathe, M.;Schumann, M.;Krause, E.;Beyermann, M.;Bienert, M. Biochemistry 1996, 35, 10844–10853.
22
Steiner, H.;Andreu, D.;Merrifield, R. B. Biochim Biophys Acta 1988, 939, 260–266.
23
Aletras, A.;Barlos, K.;Gatos, D.;Koutsogianni, S.;Mamos, P. Int J Pept Protein Res 1995, 1995, 488–496.
24
Mimee, B.;Labbe, C.;Pelletier, R.;Belanger, R. R. Antimicrob Agents Chemother 2005, 49, 1597–1599.
25
Wu, M.;Hancock, R. E. J Biol Chem 1999, 274, 29–35.
26
Choi, M. Y.;Cardarelli, L.;Therien, A. G.;Deber, C. M. Biochemistry 2004, 43, 8077–8083.
27
Chen, Y. H.;Yang, J. T.;Chau, K. H. Biochemistry 1974, 13, 3350–3359.
28
Mayer, L. D.;Hope, M. J.;Cullis, P. R. Biochim Biophys Acta 1986, 858, 161–168.
29
Deber, C. M.;Wang, C.;Liu, L. P.;Prior, A. S.;Agrawal, S.;Muskat, B. L.;Cuticchia, A. J. Protein Sci 2001, 10, 212–219.
Direct Link:
30
Deber, C. M.;Madison, V.;Blout, E. R. Acc Chem Res 1976, 9, 106–113.
31
Szewczuk, Z.;Gibbs, B. F.;Yue, S. Y.;Purisima, E. O.;Konishi, Y. Biochemistry 1992, 31, 9132–9140.
32
Unger, T.;Oren, Z.;Shai, Y. Biochemistry 2001, 40, 6388–6397.
33
Oren, Z.;Shai, Y. Biochemistry 2000, 39, 6103–6114.
34
Johnson, R. M.;Heslop, C. L.;Deber, C. M. Biochemistry 2004, 43, 14361–14369.
35
Pierce, G. E. J Ind Microbiol Biotechnol 2005, 32, 309–318.
36
Guerrero, E.;Saugar, J. M.;Matsuzaki, K.;Rivas, L. Antimicrob Agents Chemother 2004, 48, 2980–2986.
37
Tachi, T.;Epand, R. F.;Epand, R. M.;Matsuzaki, K. Biochemistry 2002, 41, 10723–10731.
38
Hui, L.;Leung, K.;Chen, H. M. Anticancer Res 2002, 22, 2811–2816.
39
Chen, Y.;Mant, C. T.;Farmer, S. W.;Hancock, R. E.;Vasil, M. L.;Hodges, R. S. J Biol Chem 2005, 280, 12316–12329.
40
Song, Y. M.;Park, Y.;Lim, S. S.;Yang, S. T.;Woo, E. R.;Park, I.S.;Lee, J. S.;Kim, J. I.;Hahm, K. S.;Kim, Y.;Shin, S. Y. Biochemistry 2005, 44, 12094–12106.
41
Ladokhin, A. S.;Jayasinghe, S.;White, S. H. Anal Biochem 2000, 285, 235–245.
42
Liu, L. P.;Li, S. C.;Goto, N. K.;Deber, C. M. Biopolymers 1996, 39, 465–470.
Direct Link:
43
Russ, W. P.;Engelman, D. M. J Mol Biol 2000, 296, 911–919.
44
Lear, J. D.;Stouffer, A. L.;Gratkowski, H.;Nanda, V.;Degrado, W. F. Biophys J 2004, 87, 3421–3429.
45
Kleiger, G.;Grothe, R.;Mallick, P.;Eisenberg, D. Biochemistry 2002, 41, 5990–5997.
46
Oren, Z.;Ramesh, J.;Avrahami, D.;Suryaprakash, N.;Shai, Y.;Jelinek, R. Eur J Biochem 2002, 269, 3869–3880.
Direct Link:
47
Hara, T.;Mitani, Y.;Tanaka, K.;Uematsu, N.;Takakura, A.;Tachi, T.;Kodama, H.;Kondo, M.;Mori, H.;Otaka, A.;Nobutaka, F.;Matsuzaki, K. Biochemistry 2001, 40, 12395–12399.

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Membrane interactions of designed cationic antimicrobial peptides: The two thresholds†

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Membrane interactions of designed cationic antimicrobial peptides: The two thresholds^†