Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes
Article first published online: 23 JUN 2010
Copyright © 2010 Wiley Periodicals, Inc.
Special Issue: Natural Products at the Core of Drug Discovery
Volume 93, Issue 9, pages 755–763, September 2010
How to Cite
Campbell, C. D. and Vederas, J. C. (2010), Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers, 93: 755–763. doi: 10.1002/bip.21428
- Issue published online: 23 JUN 2010
- Article first published online: 23 JUN 2010
- Manuscript Accepted: 4 MAR 2010
- Manuscript Revised: 12 FEB 2010
- Manuscript Received: 2 FEB 2010
- natural product;
- Diels Alderase
The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi-billion dollar drug, simvastatin (Zocor™). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels-Alderase enzyme activity is utilized in its biosynthesis. This review examines the biosynthesis of lovastatin, as well as of compactin, equisetin, cytochalasins, and solanapyrones, which are other structurally related polyketides that appear to utilize a Diels-Alderase. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 755–763, 2010.