Kathleen W. Clancy and Jeffrey A. Melvin contributed equally to this work
Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition†
Article first published online: 30 JUN 2010
Copyright © 2010 Wiley Periodicals, Inc.
Special Issue: Special Issue Dedicated to the 2009 Bruce Merrifield Award Winner Stephen B. H. Kent
Volume 94, Issue 4, pages 385–396, 2010
How to Cite
Clancy, K. W., Melvin, J. A. and McCafferty, D. G. (2010), Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition. Biopolymers, 94: 385–396. doi: 10.1002/bip.21472
This article is dedicated to Professor Stephen B. H. Kent on the occasion of his receipt of the 2009 Merrifield Award.
- Issue published online: 30 JUN 2010
- Article first published online: 30 JUN 2010
- Manuscript Revised: 20 APR 2010
- Manuscript Accepted: 20 APR 2010
- Manuscript Received: 25 FEB 2010
- National Institutes of Health Allergy and Infectious Disease Institute. Grant Number: AI46611
- virulence factor;
- enzyme structure;
- substrate specificity;
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacter a enzyme sortase. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 385–396, 2010.