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Current progress and limitations of spider silk for biomedical applications †
Article first published online: 6 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Special Issue: Silks: Properties and Uses of Natural and Designed Variants
Volume 97, Issue 6, pages 468–478, June 2012
How to Cite
Widhe, M., Johansson, J., Hedhammar, M. and Rising, A. (2012), Current progress and limitations of spider silk for biomedical applications . Biopolymers, 97: 468–478. doi: 10.1002/bip.21715
- Issue published online: 20 MAR 2012
- Article first published online: 6 SEP 2011
- Manuscript Accepted: 15 AUG 2011
- Manuscript Received: 1 JUL 2011
- Swedish Research Council, Formas, and Vinnova
- spider silk;
- cell culture
Spider silk is a fascinating material combining remarkable mechanical properties with low density and biodegradability. Because of these properties and historical descriptions of medical applications, spider silk has been proposed to be the ideal biomaterial. However, overcoming the obstacles to produce spider silk in sufficient quantities and in a manner that meets regulatory demands has proven to be a difficult task. Also, there are relatively few studies of spider silk in biomedical applications available, and the methods and materials used vary a lot. Herein we summarize cell culture- and in vivo implantation studies of natural and synthetic spider silk, and also review the current status and future challenges in the quest for a large scale production of spider silk for medical applications. © 2011 Wiley Periodicals, Inc. Biopolymers 97: 468–478, 2012.