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Abstracting knowledge from the protein data bank†
Article first published online: 29 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: PDB40: The Protein Data Bank Celebrates its 40th Birthday
Volume 99, Issue 3, pages 183–188, March 2013
How to Cite
Furnham, N., Laskowski, R. A. and Thornton, J. M. (2013), Abstracting knowledge from the protein data bank. Biopolymers, 99: 183–188. doi: 10.1002/bip.22107
- Issue published online: 21 DEC 2012
- Article first published online: 29 SEP 2012
- Accepted manuscript online: 22 JUN 2012 09:31AM EST
- Manuscript Accepted: 25 MAY 2012
- Manuscript Received: 30 APR 2012
- protein structure analysis;
- Protein Data Bank
In the 40 years since its inception, the Protein Data Bank (PDB) has amassed over 80,000 experimentally determined structural models of proteins, plus many models of DNA and RNA fragments. The majority of the protein models have contributed, in some way, to an understanding of their particular protein's function, be it through the conformation of its catalytic residues, the details of its interactions with other proteins, substrate molecules, DNA, and so on. However, the totality of the data in the PDB provides a rich source of more generalized knowledge about proteins, their molecular biology, and evolution. Here, we describe how the focus of protein structural analysis has developed over the past 40 years. © 2012 Wiley Periodicals, Inc. Biopolymers 99: 183–188, 2013.