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STUbLs in chromatin and genome stability†
Article first published online: 22 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: Chromatin Modifying Enzymes
Volume 99, Issue 2, pages 146–154, February 2013
How to Cite
Garza, R. and Pillus, L. (2013), STUbLs in chromatin and genome stability. Biopolymers, 99: 146–154. doi: 10.1002/bip.22125
- Issue published online: 22 NOV 2012
- Article first published online: 22 NOV 2012
- Accepted manuscript online: 17 JUL 2012 04:32AM EST
- Manuscript Accepted: 6 JUL 2012
- Manuscript Received: 28 APR 2012
- National Institutes of Health. Grant Numbers: GM54778, GM090177, F32-GM089101
- DNA damage;
Chromatin structure and function is based on the dynamic interactions between nucleosomes and chromatin-associated proteins. In addition to the other post-translational modifications considered in this review issue of Biopolymers, ubiquitin and SUMO proteins also have prominent roles in chromatin function. A specialized form of modification that involves both, referred to as SUMO-targeted ubiquitin ligation, or STUbL [Perry, Tainer, and Boddy, Trends Biochem Sci, 2008, 33, 201–208], has significant effects on nuclear functions, ranging from gene regulation to genomic stability. Intersections between SUMO and ubiquitin in protein modification have been the subject of a recent comprehensive review [Praefcke, Hofmann, and Dohmen, Trends Biochem Sci, 2012, 37, 23–31]. Our goal here is to focus on features of enzymes with STUbL activity that have been best studied, particularly in relation to their nuclear functions in humans, flies, and yeasts. Because there are clear associations of disease and development upon loss of STUbL activities in metazoans, learning more about their function, regulation, and substrates will remain an important goal for the future. © 2012 Wiley Periodicals, Inc. Biopolymers 99: 146–154, 2013.