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Hydration shells with a pinch of salt


  • Giuseppe Zaccai

    Corresponding author
    1. CNRS, Institut de Biologie Structurale, F-38027 Grenoble, France
    2. Institut Laue Langevin, 6 rue Jules Horowitz, 38042 Grenoble, France
    • CNRS, Institut de Biologie Structurale, F-38027 Grenoble, France
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  • This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley. com


The discovery of extreme halophile microorganisms in the Dead Sea, which are specifically dependent on a multimolar salt environment to survive, stimulated major developments in biology and physical chemistry. The minireview focuses on the molecular level. After a brief introduction to the history of halophile studies, protein and nucleic acid solvent interactions and their influence on macromolecular structure stabilization and dynamics are discussed. © 2012 Wiley Periodicals, Inc. Biopolymers 99: 233–238, 2013.