Dedication: We dedicate this review to the memory of Henryk (Heini) Eisenberg, a truly outstanding scientist, with exceptional ability to develop and apply rigorous thermodynamic and physical approaches to the analysis of biological macromolecules and their interactions. One of us (E.R.) was fortunate to have been introduced as his graduate student to the fascinating world of self-assembly of biomolecules, specifically glutamic dehydrogenase. Heini's own interest in the dynamic equilibria states of this enzyme and their regulation by nucleotides was stimulated during his sabbatical at NIH and the collaboration with Gordon M. Tomkins. With his creative mastery of thermodynamics and light scattering theories and the ability to model and predict the link between the measured parameters and the arrangement of the enzyme's subunits, Heini was ahead of his time in mapping protein substructures in the absence of crystallography data.
Article first published online: 25 JAN 2013
Copyright © 2012 Wiley Periodicals, Inc.
Special Issue: A Tribute to the Life and Science of Heini Eisenberg
Volume 99, Issue 4, pages 245–256, April 2013
How to Cite
Kudryashov, D. S. and Reisler, E. (2013), ATP and ADP actin states. Biopolymers, 99: 245–256. doi: 10.1002/bip.22155
Heini was an ideal mentor; inspiring, supportive, offering ideas, opening new vistas on how to solve challenging problems, and yet encouraging full independence and self-reliance of his students and postdoctoral fellows. He created an environment of intellectual ambition and curiosity and true excitement about learning how biomolecules function. The informal and supportive environment included also his family—his wife Nutzi and children Shai and Danny—as well as his students and postdocs families. Heini's support and friendship were a gift and asset that has accompanied me (E.R.) in all the years after I left his group. His legacy is in the outstanding publications and the scientists whose careers he helped to launch.
This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at email@example.com
- Issue published online: 25 JAN 2013
- Article first published online: 25 JAN 2013
- Accepted manuscript online: 17 SEP 2012 08:22AM EST
- Manuscript Accepted: 7 SEP 2012
- Manuscript Received: 25 JUL 2012
- USPHS. Grant Number: R01 GM077190
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