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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
bip22244-sup-0001-suppinfo.avi4483KMovie S1: Peptide Interaction with Vesicles. L-ATRA-1A is added to a microwell filled with lipid vesicles of 80:20 DOPC:DOPG (100 µg/mL). The movie shows snapshots of peptide-vesicle activity every 30 sec from t = 0 min to t = 35 min. The onset of activity begins at 23 min and results in vesicle lysing, leakage of tagged solution and vesicle fusion. Snapshots of activities are shown in Figure 7a. All scale bars correspond to 20 µm.
bip22244-sup-0002-suppinfo.avi3173KMovie S2: Peptide Interaction with Vesicles. D-ATRA-1A is added to a microwell filled with lipid vesicles of 80:20 DOPC:DOPG (100 µg/mL). The movie shows snapshots of peptide-vesicle activity every 30 sec from t = 0 min to t = 35 min. The onset of activity begins at 3 min and results in vesicle lysing, leakage of tagged solution and vesicle fusion. Snapshots of activities are shown in Figure 7b. All scale bars correspond to 20 µm.
bip22244-sup-0003-suppinfo.avi152KMovie S3: Peptide and Lipid clustering on bilayer surface. D-ATRA-1A is added to a microwell filled with lipid vesicles of 80:20 DOPC:DOPG (300 µg/mL). In single-phase vesicles, the dye is expected to be evenly distributed. The bright clusters in the bilayer in the presence of D-isomer indicate that the peptide has induced clustering, potentially between DOPG and the cationic peptide. See text for details.

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