This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at firstname.lastname@example.org
Folding of RNA tertiary structure: Linkages between backbone phosphates, ions, and water
Article first published online: 23 SEP 2013
Copyright © 2013 Wiley Periodicals, Inc.
Special Issue: 50th Anniversary Special Issue on Nucleic Acids
Volume 99, Issue 12, pages 1105–1113, December 2013
How to Cite
Draper, D. E. (2013), Folding of RNA tertiary structure: Linkages between backbone phosphates, ions, and water. Biopolymers, 99: 1105–1113. doi: 10.1002/bip.22249
- Issue published online: 23 SEP 2013
- Article first published online: 23 SEP 2013
- Accepted manuscript online: 9 APR 2013 04:35AM EST
- Manuscript Accepted: 25 MAR 2013
- Manuscript Revised: 14 MAR 2013
- Manuscript Received: 1 FEB 2013
The functional forms of many RNAs have compact architectures. The placement of phosphates within such structures must be influenced not only by the strong electrostatic repulsion between phosphates, but also by networks of interactions between phosphates, water, and mobile ions. This review first explores what has been learned of the basic thermodynamic constraints on these arrangements from studies of hydration and ions in simple DNA molecules, and then gives an overview of what is known about ion and water interactions with RNA structures. A brief survey of RNA crystal structures identifies several interesting architectures in which closely spaced phosphates share hydration shells or phosphates are buried in environments that provide intramolecular hydrogen bonds or site-bound cations. Formation of these structures must require strong coupling between the uptake of ions and release of water. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 1105–1113, 2013.