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A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis
Article first published online: 19 SEP 2013
Copyright © 2013 Wiley Periodicals, Inc.
Special Issue: International Conference on Circular Proteins
Volume 100, Issue 5, pages 433–437, September 2013
How to Cite
Gerlach, S. L., Göransson, U., Kaas, Q., Craik, D. J., Mondal, D. and Gruber, C. W. (2013), A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis. Biopolymers, 100: 433–437. doi: 10.1002/bip.22258
- Issue published online: 19 SEP 2013
- Article first published online: 19 SEP 2013
- Accepted manuscript online: 31 JUL 2013 08:38AM EST
- Manuscript Accepted: 8 APR 2013
- Manuscript Revised: 26 MAR 2013
- Manuscript Received: 27 DEC 2012
Cyclotides are a large family of plant peptides characterized by their cyclic cystine knot composed of a circular backbone and three disulfide bonds that impart exceptional stability. They, and several acyclic variants, have been isolated from plants within the Rubiaceae, Violaceae, Cucurbitaceae, Fabaceae, Solanaceae, and Poaceae families. A variety of chemical and genetic approaches have been applied for the discovery and characterization of cyclotides. As investigations of cyclotide expression, distribution, and phylogeny rapidly increase, the authors have proposed the inclusion of information pertaining to plant species that have been analyzed but do not appear to express cyclotides into the CyBase database. CyBase is dedicated to providing web tools and information about cyclic peptides and proteins to the scientific community. Including detailed information about sampling and analysis parameters of plant species that have been investigated but not published elsewhere should assist in the process of selecting species for establishing new cyclotide discovery projects, as well as for detailed reanalysis using alternative technical approaches. In summary, the collection and deposition of all plant species that have been examined (whether cyclotides have been found or not) would help to impart a deeper understanding of cyclotide discovery, evolution, and physiological function. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 433–437, 2013.