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Synthesis of temperature-dependent elastin-like peptide-modified dendrimer for drug delivery


  • Chie Kojima,

    Corresponding author
    1. Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, Japan
    • Correspondence to: Chie Kojima, Nanoscience and Nanotechnology Research Center, Research Institutes for the 21st Century, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan; e-mail:

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  • Kotaro Irie

    1. Department of Physical Science, Graduate School of Science, Osaka Prefecture University, Osaka, Japan
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  • This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at


Dendrimers are synthetic macromolecules with a unique structure that are potential unimolecular drug carriers and potential scaffolds for peptides. Elastin is one of the main components of the extracellular matrix, as well as a temperature-sensitive biomacromolecule. Val-Pro-Gly-Val-Gly repeats, an elastin-like peptide, have been used for designing artificial elastin molecules. In this study, we have synthesized a novel type of temperature-dependent drug carrier by conjugating Ac-Val-Pro-Gly-Val-Gly to a dendrimer, named elastin-mimetic dendrimer. The elastin-mimetic dendrimer formed β-turn structure by heating. The elastin-mimetic dendrimer exhibited the inverse phase transition, depending on pH and NaCl concentration in addition to temperature. The elastin-mimetic dendrimer could encapsulate a model drug, rose bengal, even though the complex stability was similar to the dendrimer without elastin-like peptide. Therefore, the elastin-mimetic dendrimer is a potential drug carrier with temperature- and pH-dependent properties. (134 words) © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 714–721, 2013.

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