Amphiphilic Cytosolic Glycans from Mycobacteria: Occurrence, Lipid-Binding Properties, Biosynthesis, and Synthesis

Authors

  • Li Xia,

    1. Alberta Glycomics Centre and Department of Chemistry, University of Alberta, Gunning–Lemieux Chemistry Centre, Edmonton, Canada
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  • Todd L. Lowary

    Corresponding author
    • Alberta Glycomics Centre and Department of Chemistry, University of Alberta, Gunning–Lemieux Chemistry Centre, Edmonton, Canada
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  • This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

Correspondence to: L. Lowary; e-mail: tlowary@ualberta.ca

ABSTRACT

Polymethylated polysaccharides (PMPSs), glycans composed of 10–20 carbohydrate residues the majority of which carry a single methyl group, are produced by some mycobacterial species. O-Methylation thus occurs on 20–30% of all the hydroxyl groups within the molecule, rendering them amphiphilic. A property of PMPSs is their ability to form high-affinity complexes with fatty acids and their derivatives, suggesting a role in mycobacterial fatty acid biosynthesis. However, direct evidence for their in vivo function is still lacking. Over the past several decades the lipid-binding properties, biosynthesis, and chemical synthesis of PMPSs have been explored and this review will provide an overview of progress made in these areas. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 697–712, 2013.

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